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Comparative Anti-Obesity Potential of Cannabigerol-Dominant Cannabis sativa L. Inflorescence Extracts via Differential Regulation of Lipid Metabolism in 3T3-L1 Cells.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, [2000-
    • Subject Terms:
      Cannabis*/chemistry ; Plant Extracts*/pharmacology ; Plant Extracts*/chemistry ; Anti-Obesity Agents*/pharmacology ; Anti-Obesity Agents*/chemistry ; Lipid Metabolism*/drug effects ; Cannabinoids*/pharmacology ; Cannabinoids*/chemistry ; Inflorescence*/chemistry; Adipogenesis/drug effects ; Obesity/drug therapy ; Obesity/metabolism ; Lipogenesis/drug effects ; Lipolysis/drug effects ; Adipocytes/drug effects ; Adipocytes/metabolism ; Animals ; 3T3-L1 Cells ; Mice
    • Abstract:
      Obesity is a chronic metabolic disorder characterized by excessive accumulation of body fat and is a major risk factor for various diseases, including type 2 diabetes, hypertension, and cardiovascular diseases. This study investigated the anti-obesity effects of cannabigerol-dominant C. sativa inflorescence extracts (CEs) obtained using various ethanol concentrations. The extracts were analyzed by UPLC to determine their major components. Additionally, anti-obesity mechanisms of the extracts were further determined through RT-qPCR and Western blot analysis to evaluate gene and protein expression levels. A total of seven cannabinoids, including cannabigerol as a major constituent, were identified within CE. Differentiation of 3T3-L1 cells was dose-dependently inhibited by CE at all ethanol concentrations. Furthermore, the gene and protein expression levels of key adipogenic and lipogenic markers, such as PPARγ, C/EBPα, SREBP-1c, and FAS, were significantly downregulated by CE treatment. In contrast, the expression of factors involved in lipolysis and white adipose tissue browning, such as HSL, ATGL, UCP1, and PGC-1α, was markedly increased by CE treatment. These effects were enhanced in an ethanol concentration-dependent manner. In conclusion, these results demonstrate that cannabigerol-dominant C. sativa effectively mitigates obesity by suppressing adipogenesis and lipogenesis while concurrently stimulating lipolysis and white adipose tissue browning.
    • Grant Information:
      2025_IK_A_2 Jeonbuk Advanced Bio Research & Development Program funded by Jeonbuk Province
    • Contributed Indexing:
      Keywords: Cannabis sativa L.; anti-obesity; cannabigerol; cannabinoid; obesity
    • Accession Number:
      0 (Plant Extracts)
      0 (Anti-Obesity Agents)
      0 (Cannabinoids)
      J1K406072N (cannabigerol)
    • Publication Date:
      Date Created: 20260227 Date Completed: 20260305 Latest Revision: 20260305
    • Publication Date:
      20260306
    • Accession Number:
      PMC12941217
    • Accession Number:
      10.3390/ijms27041747
    • Accession Number:
      41751885