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Cerebral arterial stiffness is linked to white matter hyperintensities and perivascular spaces in older adults – A 4D flow MRI study

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  • Additional Information
    • Publication Information:
      SAGE Publications, 2024.
    • Publication Date:
      2024
    • Abstract:
      White matter hyperintensities (WMH), perivascular spaces (PVS) and lacunes are common MRI features of small vessel disease (SVD). However, no shared underlying pathological mechanism has been identified. We investigated whether SVD burden, in terms of WMH, PVS and lacune status, was related to changes in the cerebral arterial wall by applying global cerebral pulse wave velocity (gcPWV) measurements, a newly described marker of cerebral vascular stiffness. In a population-based cohort of 190 individuals, 66–85 years old, SVD features were estimated from T1-weighted and FLAIR images while gcPWV was estimated from 4D flow MRI data. Additionally, the gcPWV’s stability to variations in field-of-view was analyzed. The gcPWV was 10.82 (3.94) m/s and displayed a significant correlation to WMH and white matter PVS volume (r = 0.29, p
    • File Description:
      application/pdf
    • ISSN:
      1559-7016
      0271-678X
    • Accession Number:
      10.1177/0271678x241230741
    • Rights:
      CC BY NC
      URL: http://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (http://us.sagepub.com/en-us/nam/open-access-at-sage).
    • Accession Number:
      edsair.doi.dedup.....0edfaa7de290a5d4aae54ad2a56ac715