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Markers of T-cell dysfunction and not inflammaging predict the waning of humoral responses to SARS-CoV-2 mRNA booster vaccination in people with HIV

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  • Additional Information
    • Publication Information:
      Ovid Technologies (Wolters Kluwer Health), 2024.
    • Publication Date:
      2024
    • Abstract:
      In this prospective longitudinal study, we evaluated the durability of humoral responses to SARS-CoV-2 mRNA booster vaccination in 93 people with HIV, exploring the possible role of T-cell dysfunction and inflammaging biomarkers in predicting antibody waning. We found that, despite a negligible influence of the inflammaging milieu, low CD4/CD8 ratio and CD4+CD127+ percentage as well as high CD8+CD38+CD45RO+ percentage are associated with faster antibody waning, in turn contributing to our understanding of the determinants of COVID-19 vaccine-elicited immune response in this population.
    • ISSN:
      1473-5571
      0269-9370
    • Accession Number:
      10.1097/qad.0000000000004010
    • Rights:
      CC BY
      URL: http://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (http://creativecommons.org/licenses/by/4.0/)
    • Accession Number:
      edsair.doi.dedup.....24447e9a11dd7e080d103e4b49c4a984