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Can antibodies be 'vegan'? A guide through the maze of today’s antibody generation methods

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  • Additional Information
    • Publication Information:
      Informa UK Limited, 2024.
    • Publication Date:
      2024
    • Abstract:
      There is no doubt that today's life sciences would look very different without the availability of millions of research antibody products. Nevertheless, the use of antibody reagents that are poorly characterized has led to the publication of false or misleading results. The use of laboratory animals to produce research antibodies has also been criticized. Surprisingly, both problems can be addressed with the same technology. This review charts today's maze of different antibody formats and the various methods for antibody production and their interconnections, ultimately concluding that sequence-defined recombinant antibodies offer a clear path to both improved quality of experimental data and reduced use of animals.
    • File Description:
      13 Seiten
    • ISSN:
      1942-0870
      1942-0862
    • Accession Number:
      10.1080/19420862.2024.2343499
    • Rights:
      CC BY NC
      URL: http://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (http://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
    • Accession Number:
      edsair.doi.dedup.....6c62baecc12ab665b36f41ae95ec4460