Abstract: Background Active commuting (i.e., walking and cycling to work) could have public health benefits while simultaneously fostering climate change mitigation. Current evidence suggests that regular physical activity decreases circulating C-reactive protein (CRP) levels. Yet, it is unclear whether active commuting is associated with lower CRP levels. Study aims: To explore the association between active commuting and CRP levels in working Finnish residents. Our hypothesis is that CRP levels are lower in active commuters than passive commuters. Methods A total of 6208 working Finnish residents were drawn from the FINRISK population surveys of years 1997, 2002, 2007 and 2012. We cross-sectionally analysed the association between active commuting, defined as the time spent walking or cycling to work daily, and high sensitivity (hs-) CRP serum levels in this sample. For the analyses, we used linear and additive models, and we adjusted for potential confounders. Results Participants who engaged in a minimum of 45 minutes of daily active commuting had 16.8% (95% confidence interval, CI: -25.6%, -7.0%) lower hs-CRP than passive commuters. The direction of the association in the main model was the same when active commuting lasted 15-29 minutes daily (% mean difference: -7.4; 95% CI: -14.1, -0.2), but the estimates lacked precision after adjusting for leisure-time physical activity and diet. In subgroup analyses, we observed associations for women. Conclusions High level of active commuting, at least 45 minutes a day, was associated with reduced low-grade inflammation; the association was driven by women. Key messages • Promoting active commuting could help reduce many chronic diseases. • Active modes of transport, such as walking and cycling, may not only be an alternative to motorized vehicles to decrease emissions, but they may also have public health benefits.
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