Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Contributors:
      Medina, Luciana; González-Lizárraga, Florencia; Dominguez-Meijide, Antonio; Ploper, Diego; Parrales, Valeria; Sequeira, Sabrina; Cima-Omori, Maria-Sol; Zweckstetter, Markus; Del Bel, Elaine; Socias, Sergio B.; Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET); Universidade de Santiago de Compostela [Spain] (USC ); Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED); Instituto de Salud Carlos III [Madrid] (ISC); University of Göttingen - Georg-August-Universität Göttingen; Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM); Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP]; Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS); German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE); Max-Planck-Institut für Biophysikalische Chemie - Max Planck Institute for Biophysical Chemistry [Göttingen]; Max-Planck-Gesellschaft; University of São Paulo (USP); Max Planck Institute of Experimental Medicine [Göttingen] (MPI); Newcastle University [Newcastle]
    • Publication Information:
      Frontiers Media SA, 2021.
    • Publication Date:
      2021
    • Abstract:
      Tauopathies are neurodegenerative disorders with increasing incidence and still without cure. The extensive time required for development and approval of novel therapeutics highlights the need for testing and repurposing known safe molecules. Since doxycycline impacts α-synuclein aggregation and toxicity, herein we tested its effect on tau. We found that doxycycline reduces amyloid aggregation of the 2N4R and K18 isoforms of tau protein in a dose-dependent manner. Furthermore, in a cell free system doxycycline also prevents tau seeding and in cell culture reduces toxicity of tau aggregates. Overall, our results expand the spectrum of action of doxycycline against aggregation-prone proteins, opening novel perspectives for its repurposing as a disease-modifying drug for tauopathies.
    • File Description:
      application/pdf
    • ISSN:
      1663-4365
    • Accession Number:
      10.3389/fnagi.2021.635760
    • Accession Number:
      10.60692/4vjhz-cyr54
    • Accession Number:
      10.60692/jz0b6-51f96
    • Rights:
      CC BY
    • Accession Number:
      edsair.doi.dedup.....9fba948b81dc65e61bfaf00de94d661a