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Pain thresholds and intensities of CRPS type I and neuropathic pain in respect to sex

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  • Additional Information
    • Contributors:
      Physiopathologie et Pharmacologie Clinique de la Douleur (LPPD); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ); Innovative Medicines Initiative, IMI: 115007 Research School, Ruhr University Bochum, RS, RUB Syddansk Universitet, SDU Universität Ulm, UULM Albert-Ludwigs-Universität Freiburg Bundesministerium für Bildung und Frauen, BMBF: 01EM0902 Karolinska Institutet, KI; The IMI EUROPAIN project has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement No. 115007. The NEUROPAIN project was supported by an independent investigator-initiated research grant from Pfizer Ltd. German Research Network on Neuropathic pain (DFNS) is supported by the German Ministry of Education and Research (BMBF; Grant No. 01EM0902). The IMI EUROPAIN project is a public-private partnership/ EU-Project for understanding chronic pain and improving its treatment. The NEUROPAIN project for the characterization of subgroups of patients with neuropathic pain is an investigator-initiated European multicentre study with Prof. Dr. R. Baron as principle investigator and ten co-investigator sites. Data for these consortia was collected at the following sites: Johannes Gutenberg-University, Mainz, Germany, University of Schleswig-Holstein, Kiel, Germany, Ruhr University Bochum, Germany, Technical University Munich, Germany, Ludwig-Maximilians-University, Munich, Germany, University of T?bingen, Germany, University of Freiburg, Germany, University of Ulm, Germany, University of Erlangen, Germany, Benedictus Hospital Tutzing, Germany, Aarhus University, Denmark, University of Southern Denmark, Odense, Denmark, Karolinska Institute, Stockholm, Sweden, Imperial College London, UK, Neuroscience Technologies, Barcelona, Spain.; Department of Diagnostics and Therapeutics; Clinicum; Helsinki University Hospital Area
    • Publication Date:
      2020
    • Abstract:
      International audience; Background and Aims: Healthy women have generally been found to have increased experimental pain perception and chronic pain has a higher prevalence in female as compared to male patients. However, no study has investigated whether pain intensity and pain perception thresholds are distinct or similar between sexes within various chronic pain entities. We investigated whether average pain intensities and pain thresholds assessed using quantitative sensory testing (QST) differed between women and men suffering from three distinct chronic pain conditions: Complex Regional Pain Syndrome (CRPS type I), peripheral nerve injury (PNI) or polyneuropathy (PNP), as compared to paired healthy volunteers. Methods: QST data of 1,252 patients (669 female, 583 male) with PNI (n = 342), PNP (n = 571) or CRPS (n = 339), and average pain intensity reports from previously published studies were included. Absolute and z-values (adjusted for age and body region) of cold, heat, pressure (PPT) and pinprick pain thresholds were compared in generalized linear models with aetiology, duration of underlying pain disease and average pain intensity as fixed effects. Results: Average pain intensity during the past four weeks did not differ between women and men, in both mean and range. In women absolute pain thresholds for cold, heat and pinprick were lower than in males across all diagnoses (p
    • File Description:
      application/pdf
    • ISSN:
      1090-3801
    • Accession Number:
      10.1002/ejp.1550
    • Accession Number:
      10.1002/ejp.1550⟩
    • Rights:
      OPEN
    • Accession Number:
      edsair.doi.dedup.....a414a71472b63d80cd99c7d654b28b9d