Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Evolution and Mutations of Beta 2 Microglobulin

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Publication Information:
      Preprint
    • Publication Information:
      Elsevier BV, 2022.
    • Publication Date:
      2022
    • Abstract:
      Here we examine the evolution of beta-2 microglobulin in terms of its hydropathic shapes, a theoretical construct that has revealed important trends. The dynamics of many proteins are largely driven by interactions between the protein itself and the thin water film that covers it. \b{eta}2m constitutes the basic building unit of the immunoglobulin superfamily; the evolution of its amino acid sequences from chickens to mice to humans provides new information about its multiple functions. Our hydrodynamic method involves concepts of topological shape evolution towards a critical point for optimized functions. The results are in excellent agreement with experiment for the details of the mouse-human evolution, as well as both the dangerous natural amyloid aggregation mutation D76N, and six other DN test mutations.
      10 pages, 4 figures
    • ISSN:
      1556-5068
    • Accession Number:
      10.2139/ssrn.4066974
    • Accession Number:
      10.48550/arxiv.2202.09847
    • Rights:
      CC BY
    • Accession Number:
      edsair.doi.dedup.....b7db2d83b4801b5147f4e5cd1dace52e