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Three unconventional maxims in the natural selection of cancer cells: Generation of induced tumor-suppressing cells (iTSCs)

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  • Additional Information
    • Contributors:
      Biomedical Engineering, School of Engineering and Technology
    • Publication Information:
      Ivyspring International Publisher, 2023.
    • Publication Date:
      2023
    • Abstract:
      Induced tumor-suppressing cells (iTSCs) can be generated from cancer and non-cancer cells. Here, three paradoxical maxims for the action of iTSCs are reviewed: the secretion of tumor-suppressing proteins, their role as a "double-edged" sword, and the elimination of lesser-fit cancer cells. "Super-fit" cancer cells secrete an array of proteins, most of which contribute to enhancing their growth and removing "lesser-fit" cancer cells. These maxims explain the potential dilemma with therapeutic agents since the inhibitory agents tend to promote the synthesis of tumor-promoting proteins. The maxims suggest the possibility of a novel treatment option using cancer-guided evolutionary-fit iTSCs.
    • File Description:
      application/pdf
    • ISSN:
      1449-2288
    • Accession Number:
      10.7150/ijbs.79155
    • Rights:
      CC BY
      URL: http://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
    • Accession Number:
      edsair.doi.dedup.....cb31f4646136244f01eaed4f6b67dd08