Contributors: Hansen, Niels; Singh, Aditya; Bartels, Claudia; Brosseron, Frederic; Buerger, Katharina; Cetindag, Arda C.; Dobisch, Laura; Dechent, Peter; Ertl-Wagner, Birgit B.; Goya-Maldonado, Roberto; Fliessbach, Klaus; Haynes, John D.; Heneka, Michael T.; Janowitz, Daniel; Kilimann, Ingo; Laske, Christoph; Metzger, Coraline D.; Munk, Matthias H.; Peters, Oliver; Priller, Josef; Roy, Nina; Scheffler, Klaus; Schneider, Anja; Spottke, Annika; Spruth, Eike J.; Teipel, Stefan; Tscheuschler, Maike; Vukovich, Ruth; Wiltfang, Jens; Duezel, Emrah; Jessen, Frank; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; 5German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany; 7Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany; 9German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany; 10MR-Research in Neurology and Psychiatry, University Medical Center Göttingen, Göttingen, Germany; 11Institute for Clinical Radiology, Ludwig-Maximilians-University, Munich, Germany; 12Bernstein Center for Computational Neuroscience, Charité—Universitätsmedizin, Berlin, Germany; 6Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany; 13German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany; 15German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany; 8German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany; 21Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany; 23Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany
Abstract: Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases.Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups.Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and mood disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode.Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BD, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups.
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