Abstract: Studies have suggested that hormone receptor and Ki67 expression in normal breast tissue are associated with subsequent breast cancer risk. We examined the associations of breast cancer risk factors with estrogen receptor (ER), progesterone receptor (PR), insulin-like growth factor-1 receptor (IGF-1R), and Ki67 expression in normal breast tissue. This analysis included 388 women with benign breast disease (ages 17–67 years) in the Nurses’ Health Studies. Immunohistochemical staining was performed on tissue microarrays constructed from benign biopsies containing normal breast epithelium and scored as the percentage of epithelial cells that were positively stained. Ordinal logistic regression (outcomes in tertiles), adjusting for age and potential confounders, was performed to estimate odds ratios (OR) and 95% confidence intervals (CI) for the associations with risk factors. Alcohol consumption was positively associated (≥2.5 vs.
Risk factors: Alcohol, breastfeeding and body traits tied to molecular biomarkers Body size, alcohol intake and breastfeeding may affect the molecular features of normal breast tissue to influence cancer risk. A team led by Hannah Oh from the Harvard T. H. Chan School of Public Health in Boston, USA, examined the link between behavioral and physiological risk factors for breast cancer and the expression levels of certain proteins (such as hormone receptors) that also promote cancer formation. By examining healthy breast tissue biopsied from 388 women diagnosed with benign breast diseases, the researchers showed that alcohol consumption, height and body mass index were all positively associated with the expression of various breast tissue markers, while breastfeeding and early-life body size were inversely associated. The findings point to a connection between lifestyle and breast tissue-specific molecular characteristics that underpin cancer risk.
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