Abstract: This is the final version. Available from Elsevier via the DOI in this record. ; Data availability: Data will be made available on request. ; Dietary nitrate (NO3-) supplementation can enhance nitric oxide (NO) bioavailability and lower blood pressure (BP) in humans. The nitrite concentration ([NO2-]) in the plasma is the most commonly used biomarker of increased NO availability. However, it is unknown to what extent changes in other NO congeners, such as S-nitrosothiols (RSNOs), and in other blood components, such as red blood cells (RBC), also contribute to the BP lowering effects of dietary NO3-. We investigated the correlations between changes in NO biomarkers in different blood compartments and changes in BP variables following acute NO3- ingestion. Resting BP was measured and blood samples were collected at baseline, and at 1, 2, 3, 4 and 24 h following acute beetroot juice (∼12.8 mmol NO3-, ∼11 mg NO3-/kg) ingestion in 20 healthy volunteers. Spearman rank correlation coefficients were determined between the peak individual increases in NO biomarkers (NO3-, NO2-, RSNOs) in plasma, RBC and whole blood, and corresponding decreases in resting BP variables. No significant correlation was observed between increased plasma [NO2-] and reduced BP, but increased RBC [NO2-] was correlated with decreased systolic BP (rs = -0.50, P = 0.03). Notably, increased RBC [RSNOs] was significantly correlated with decreases in systolic (rs = -0.68, P = 0.001), diastolic (rs = -0.59, P = 0.008) and mean arterial pressure (rs = -0.64, P = 0.003). Fisher's z transformation indicated no difference in the strength of the correlations between increases in RBC [NO2-] or [RSNOs] and decreased systolic blood pressure. In conclusion, increased RBC [RSNOs] may be an important mediator of the reduction in resting BP observed following dietary NO3- supplementation. ; University of Exeter ; China Scholarship Council
Relation: https://www.ncbi.nlm.nih.gov/pubmed/37268184; Nitric Oxide, 138-139; orcid:0000-0003-2546-5667 (Vanhatalo, Anni); orcid:0000-0001-9798-0612 (Black, Matthew I); ScopusID: 55580906100 (Black, Matthew I); ResearcherID: ABE-2880-2021 (Black, Matthew I); orcid:0000-0002-9613-1202 (Winyard, Paul G); ScopusID: 7005108335 (Winyard, Paul G); ResearcherID: B-6743-2011 (Winyard, Paul G); orcid:0000-0002-2082-1709 (Jones, Andrew M); ScopusID: 7407101756 (Jones, Andrew M); Vol. 138-139, pp. 1-9; https://doi.org/10.1016/j.niox.2023.05.008; http://hdl.handle.net/10871/134230; Nitric Oxide
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