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Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from Papua New Guinea

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  • Additional Information
    • Publication Information:
      American Society of Tropical Medicine and Hygiene
    • Publication Date:
      2005
    • Collection:
      Queensland University of Technology: QUT ePrints
    • Abstract:
      The cytoadherence-linked asexual gene 9 (clag 9) of Plasmodium falciparum has been implicated in the cytoadherence of infected erythrocytes. To determine the immunogenicity of the clag 9 gene product (CLAG 9 protein) in humans, we measured antibody responses to 11 synthetic CLAG 9 peptides in a group of 177 asymptomatic children and adults subject to intense malaria exposure in Madang, Papua New Guinea. The CLAG 9 peptides were immunogenic in adults and children. Antibody responses to peptides 4 and 10 were high across all age groups and detectable in a majority of children less than five years of age. While CLAG 9 peptides are immunogenic in humans, longitudinal studies will be required to determine the longevity of antibody responses to CLAG 9 and their role in protection from disease.
    • File Description:
      application/pdf
    • Relation:
      https://eprints.qut.edu.au/199833/1/49327524.pdf; http://www.ajtmh.org/docserver/fulltext/14761645/72/6/0720708.pdf?expires=1589248676&id=id&accname=guest&checksum=A182E83221AE5C905F32B8B2B6CFA458; Trenholme, Katharine R., Boutlis, Craig S., Kuns, Rachel, Lagog, Moses, Bockarie, Moses J., Gatton, Michelle L., Kemp, David J., Good, Michael F., Anstey, Nicholas M., & Gardiner, Donald L. (2005) Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from Papua New Guinea. American Journal of Tropical Medicine and Hygiene, 72(6), pp. 708-713.; https://eprints.qut.edu.au/199833/; Faculty of Health; Faculty of Science and Technology; School of Life Sciences; School of Public Health & Social Work
    • Online Access:
      https://eprints.qut.edu.au/199833/
    • Rights:
      free_to_read ; 2005 The American Society of Tropical Medicine and Hygiene ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au
    • Accession Number:
      edsbas.12E16F5E