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Additional file 1 of Deficiency in nucleoside diphosphate kinase B leads to endothelial activation of the hexosamine biosynthesis pathway and cardiac dysfunction ...

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  • Additional Information
    • Publication Information:
      figshare
    • Publication Date:
      2025
    • Collection:
      DataCite Metadata Store (German National Library of Science and Technology)
    • Abstract:
      Supplementary Material 1. Fig. 1. NDPKB-/- mice are glucose intolerant, but have normal insulin secretion. Statistical analysis of GTT (A) and blood insulin levels after GTT (B) in NDPKB-/- mice. (C) Statistical analysis of ITT in 8-month NDPKB-/- mice. n=7-8. Statistical analysis of the insulin secretion in islets isolated from NDPKB-/- mice (D). n=23-30. Statistical analysis of the glucagon secretion in islets isolated from NDPKB-/- mice (E). n=15-20. *p<0.05. Fig. 2. Fibronectin is expressed in vasculature. Immunofluorescence staining of fibronectin and lectin (a vascular marker) in the mouse LVs. Green: lectin, red: fibronectin. n=3. Scale bar=20µm. Fig. 3. Accumulation of collagen is evident in the LVs of NDPKB-/- mice. Sirius-red staining of whole heart (A) and statistical analysis in NDPKB-/- and WT LVs (B). n=5. ***p<0.001. Scale bar=500µm. Fig. 4. HBP-related proteins remain unchanged in CFs isolated from NDPKB¬ /- mice. Immunoblotting (A) and statistical analysis of O-GlcNAc (B), GFAT (C), ...
    • Relation:
      https://dx.doi.org/10.6084/m9.figshare.28463144; https://dx.doi.org/10.1186/s12933-025-02633-8
    • Accession Number:
      10.6084/m9.figshare.28463144.v2
    • Online Access:
      https://dx.doi.org/10.6084/m9.figshare.28463144.v2
      https://springernature.figshare.com/articles/presentation/Additional_file_1_of_Deficiency_in_nucleoside_diphosphate_kinase_B_leads_to_endothelial_activation_of_the_hexosamine_biosynthesis_pathway_and_cardiac_dysfunction/28463144/2
    • Rights:
      Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcode ; cc-by-4.0
    • Accession Number:
      edsbas.19151CB8