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Carboxymethyl cellulose-based hydrogel film combined with berberine as an innovative tool for chronic wound management

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  • Additional Information
    • Contributors:
      Cometa, S.; Licini, C.; Bonifacio, M. A.; Mastrorilli, P.; Mattioli-Belmonte, M.; De Giglio, E.
    • Publication Date:
      2022
    • Collection:
      Università degli Studi di Bari Aldo Moro: CINECA IRIS
    • Abstract:
      Polysaccharide-based hydrogels are achieving remarkable performances in chronic wounds treatment. In this work, a carboxymethyl cellulose-based hydrogel film was developed to support skin repair. The hydrogel was loaded with berberine, a polyphenolic molecule endowing antioxidant and cytoprotective features. The film was physico-chemically characterized and in vitro tested on keratinocytes and fibroblasts subjected to oxidative stress. The biocomposite showed high thermal stability (onset decomposition temperature 245 °C) and significant fluid uptake performances, both in free conditions (up to 6510%) and under external pressure (up to 3400%). Moreover, it was able to control oxidative stress and inflammation markers involved in wound chronicity. Keratinocytes hyperproliferation, features that normally hamper injury restoration, was reduced of 25%. Our results showed that the combination of berberine and hydrogel provides a synergic improvement of the material properties. The biocomposite represents a promising candidate for dermatological applications against oxidative stress at the chronic wound site, promoting the healing process.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/35153024; info:eu-repo/semantics/altIdentifier/wos/WOS:000761118200004; volume:283; firstpage:119145; journal:CARBOHYDRATE POLYMERS; https://hdl.handle.net/11586/383524
    • Accession Number:
      10.1016/j.carbpol.2022.119145
    • Online Access:
      https://hdl.handle.net/11586/383524
      https://doi.org/10.1016/j.carbpol.2022.119145
    • Rights:
      info:eu-repo/semantics/openAccess
    • Accession Number:
      edsbas.19E367B3