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Co-delivery of gemcitabine and Triapine by calcium carbonate nanoparticles against chemoresistant pancreatic cancer

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  • Additional Information
    • Publication Information:
      Netherlands, Elsevier
    • Publication Date:
      2023
    • Collection:
      University of Western Sydney (UWS): Research Direct
    • Abstract:
      Pancreatic cancer is a malignant disease with high mortality, and its systemic treatment strategy mainly focuses on chemotherapy. Yet, the overall prognosis of pancreatic cancer patients is still extremely poor with a low survival rate. Gemcitabine (GEM) is a widely used chemotherapeutic agent for the treatment of pancreatic cancer. However, GEM chemoresistance remains the major challenge. In this study, we prepared calcium carbonate nanoparticles (CaCO3 NPs) loaded with a nucleotide reductase inhibitor (Triapine) and GEM to suppress the GEM resistance of pancreatic cancer cells (PANC-1/GEM) and solve the problem of poor solubility of Triapine. CaCO3-GEM-Triapine NPs nano-formulations enhanced the therapeutic effect of GEM-based chemotherapy by inhibiting cancer cell proliferation, migration, and resistance to GEM using both 2D PANC-1/GEM cells and 3D tumor spheroids. The study indicated that CaCO3 NPs loaded with GEM and Triapine could provide an effective treatment option to overcome drug resistance in pancreatic cancer.
    • File Description:
      print
    • Relation:
      NHMRC 1112258; http://purl.org/au-research/grants/nhmrc/1112258; International Journal of Pharmaceutics--0378-5173--1873-3476 Vol. 636 Issue. No. 122844 pp: -
    • Accession Number:
      10.1016/j.ijpharm.2023.122844
    • Online Access:
      https://doi.org/10.1016/j.ijpharm.2023.122844
      https://hdl.handle.net/1959.7/uws:72111
    • Rights:
      © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
    • Accession Number:
      edsbas.1D8F2510