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Analyzing and Modeling the Spread of SARS-CoV-2 Omicron Lineages BA.1 and BA.2, France, September 2021–February 2022

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  • Additional Information
    • Contributors:
      Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC); Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM); Pathogenesis and Control of Chronic and Emerging Infections (PCCEI); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-Etablissement français du don du sang Montpellier -Université de Montpellier (UM); Laboratoire CERBA Saint Ouen l'Aumône; Etablissement français du don du sang Montpellier; Université de Monastir - University of Monastir (UM); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Université Paris 8 Vincennes-Saint-Denis (UP8); Centre interdisciplinaire de recherche en biologie (CIRB); Labex MemoLife; École normale supérieure - Paris (ENS-PSL); Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris); Université Paris Sciences et Lettres (PSL)-École normale supérieure - Paris (ENS-PSL); Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); projet MODVAR, financement ANRS0151; ANR-20-COVI-0098,PHYEPI,Intégration de données de séquences et d'incidence pour analyser et contrôler les épidémies virales(2020)
    • Publication Information:
      CCSD
      Centers for Disease Control and Prevention
    • Publication Date:
      2022
    • Collection:
      Université de Montpellier: HAL
    • Abstract:
      International audience ; We analyzed 324,734 SARS-CoV-2 variant screening tests from France enriched with 16,973 whole-genome sequences sampled during September 1, 2021–February 28, 2022. Results showed the estimated growth advantage of the Omicron variant over the Delta variant to be 105% (95% CI 96%–114%) and that of the BA.2 lineage over the BA.1 lineage to be 49% (95% CI 44%–52%). Quantitative PCR cycle threshold values were consistent with an increased ability of Omicron to generate breakthrough infections. Epidemiologic modeling shows that, in spite of its decreased virulence, the Omicron variant can generate important critical COVID-19 activity in hospitals in France. The magnitude of the BA.2 wave in hospitals depends on the level of relaxing of control measures but remains lower than that of BA.1 in median scenarios.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/35642476; PUBMED: 35642476; PUBMEDCENTRAL: PMC9239895; WOS: 000830154100006
    • Accession Number:
      10.3201/eid2807.220033
    • Online Access:
      https://hal.science/hal-03714983
      https://hal.science/hal-03714983v1/document
      https://hal.science/hal-03714983v1/file/SofoneaEtal2022_EID.pdf
      https://doi.org/10.3201/eid2807.220033
    • Rights:
      http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
    • Accession Number:
      edsbas.2166D40E