The role of histone deacetylase inhibitors in latency prevention and reversal.

A) GFP median fluorescence intensity (MFI) within GFP + cells in HIV-GFP- or HIV-GFP-Vpr-infected cells treated with histone deacetylase inhibitor (HDACi) for 14 days. Results are normalized to GFP MFI within HIV-GFP-infected cells for each condition. B-C) Latency reversal versus latency prevention: Cells infected with HIV-GFP or HIV-GFP-Vpr were cultured for 14 days as in A). After 14 days (14dpi), DMSO-treated cells were treated with VOR (vorinostat) for 24h before B) %GFP + cells and C) GFP MFI within GFP + cells was assessed by flow cytometry. (TIF)