Abstract: The 18 patients with stomach cancer were investigated. This group was divided in to two groups 9 people in each: one with psychotherapeutic treatment 3 men and 6 women aged from 51 to 68 years (with III stage 8 patients and with I stage 1 patient); another one with surgical treatment (control subgroup) consists of 5 men and 4 women aged from 51 to 71 years (III stage).A special method of hypnosuggestive therapy (HST) devised for this situation to modify psychosomatic disorders was used. A level of CD34+ was measured before HST and after 1 month and telomere length as well as apoptosis were measured in lymphocytes before HST and after 3, 5, 7, 9 and 11 weeks. In control group a telomere length in lymphocytes was measured. In both subgroups of patients with cancer a telomere lengths were 500 b.p. shorter than in donors before treatment. Consequently HST after 7 weeks treatment significant telomere length elongation on 1000 b.p. and apoptosis increase to 1,7% were found. Hereby these results have shown that hypnosuggestive therapy reintegrats immune system in cancer patients which discover new key points for psycho immunological investigations. (Med. Immunol., vol. 10, N 6, pp 527-534). ; Резюме. В исследовании приняли участие 18 больных раком желудка, составившие 2 группы по 9 человек: психотерапевтическая группа – 3 мужчины и 6 женщин в возрасте 51-68 лет (III стадия – 8 больных, II ст. – 1 больная); контрольная группа – 5 мужчин и 4 женщины в возрасте 51-70 лет (предварительно III ст.), которым предстояло оперативное лечение. Применялась специально разработанная методика гипносуггестивной психотерапии (ГСП) для коррекции психосоматических расстройств у онкобольных. До ГСП и через 1 месяц определялся в крови уровень CD34+, а также определялась длина теломер в лимфоцитах и уровень апоптоза лимфоцитов до ГСП, через 3, 5, 7, 9, 11 недель. В контрольной группе определялась длина теломер в лимфоцитах. У онкобольных обеих групп обнаружено сокращение длины теломер в лимфоцитах в среднем на 500 п.н. На фоне ГСП ...
Relation: https://www.mimmun.ru/mimmun/article/view/259/261; Абрамов В.В., Абрамова Т.Я., Егоров Д.Н. Высшая нервная деятельность и иммунитет. – Новосибирск: СО РАМН, 2001. – 123 с.; Антонов В.Г., Козлов В.К. Патогенез онкологических заболеваний: иммунные и биохимические феномены и механизмы. Внеклеточные и клеточные механизмы общей иммунодепрессии и иммунной резистентности // Цитокины и воспаление. – 2004. – Т. 3, № 1. – С. 8-19.; Архангельский А.Е. Психопатология беременности, родов и послеродового периода. – СПб., 2007. – 80 с.; Борисов В.И. Укорочение длины теломерных районов ДНК при иммунодефицитных, аллергических и аутоиммунных состояниях: Дис. … канд. биол. наук: спец. – Новосибирск, 2007. – 125 с.; Корнева Е.А. Введение в иммунофизиологию. – СПб.: ЭЛБИ, 2003. – 48 с.; Бухтояров О.В., Кожевников В.С., Шишков А.А., Селедцов В.И., Козлов В.А. Психологическая и иммунная защита онкологических больных – две составляющие одной проблемы // Вопр. онкологии. – 2005. – Т. 51, № 6. – С. 703-707.; Ader R., Felten D.L., Cohen N. Psychoneuroimmunology. – San Diego: Academic Press, 2001. – 1583 p.; Atesci F.C., Baltalarli B., Oguzhanoglu N.K. Psychiatric morbidity among cancer patients and awareness of illnes // Supp. Care Cancer. – 2004. – Vol. 12, N 3. – Р. 161-167.; Barak Y. The immune system and happiness // Autoimmun. Rev. – 2006. – Vol. 5, N 8. – Р. 523 - 527.; Besedovsky H.O. A.D. Rey Physiology of psychoneuroimmunology: a personal view // Brain Behav. Immun. – 2007. – Vol. 21, N 1. – Р. 34-44.; Caspi A., Sugden K., Moffitt T.E Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene // Science. – 2003. – Vol. 301, № 5631. – Р. 386-389.; Conti A. Oncology in neuroimmunomodulation: what progress has been made? // Ann. NY Acad. Sci. – 2000. – Vol. 917. – Р. 68-83.; Cottler-Fox M.H., Lapidot T., Petit I. Stem сell mobilization // Hematology. – 2003. – Р. 419-437.; Forlenza M.J., Latimer J.J., Baum A. The effects of stress on DNA repair // Psychol. Health: An Int. J. – 2000. – Vol. 15. – P. 881-981.; Gidron Y., Russ K., Tissarchondou H. The relation between psychological factors and DNA - damage: a critical review // Biol. Psychol. – 2006. – Vol. 72, N 3. – Р. 291-304.; Gruzelier J.H. A review of the impact of hypnosis, relaxation, guided imagery and individual differences on aspects of immunity and health // Stress. – 2002. – Vol. 5, N 2. – P. 147-163.; Hall N.R., McGillis J.P., Spangelo B.L. Evidence that thymosins and other biological response modifiers can function as neuroactive immunotransmitters // J. Immunol. – 1985. – N 135. – Р. 806-811.; Halliwell B. Oxidative stress and cancer: have we moved forward? // Biochem. J. – 2007. – Vol. 401, N 1. – Р. 1-11.; Hidderley M., Holt M. A pilot randomized trial assessing the effects of autogenic training in early stage cancer patients in relation to psychological status and immune system responses // Eur. J. Oncol. Nurs. – 2004. – Vol. 8, N 1. – P. 61-65.; Hudacek K.D. A review of the effects of hypnosis on the immune system in breast cancer patients: a brief communication // Int. J. Clin. Exp. Hypn. – 2007. – Vol. 55, N 4. – Р. 411-425.; Keller M., Sommerfeldt S., Fischer C., Knight L., Riesbeck M., Löwe B., Herfarth C., Lehnert T. Recognition of distress and psychiatric morbidity in cancer patients: a multi-method approach // Ann. Onc. – 2004. – Vol. 15, N 8. – Р. 1243-1249.; Kiecolt-Glaser J.K., MaruchaPh.T., Atkinson C. Hypnosis as a modulator of cellular immune dysregulation during acute stress // J. Consul. Clin. Psychol. – 2001. – Vol. 69, N 4. – P. 674-682.; Kiecolt-Glaser J.K., Robles T.F., Heffner K.L. Psycho-oncology and cancer: psychoneuroimmunology and cancer // Ann. Oncol. – 2002. – Vol. 13, N 4. – Р. 165-169.; Lawsin C., DuHamel K., Itzkowitz S.H. Demographic, medical, and psychosocial correlates to CAM use among survivors of colorectal cancer // Support Care Cancer. – 2007. – Vol. 15, N 5. – Р. 557-564.; Lewis C., O’Brien R., Barraclough J. The psychoimmunology of сancer. – N.Y.: Oxford Univ. Press, 2002. – 272 p.; Lutgendorf S.K., Sood A.K. , Anderson B. Social support, psychological distress, and natural killer cell activity in ovarian cancer // J. Clin. Oncol. – 2005. – Vol. 23, N 28. – Р. 7105-7113.; McGuire T.R., Kessinger A., Hock L. Elevated transforming growth factor beta levels in the plasma of cytokine-treated cancer patients and normal allogeneic stem cell donors // Cytotherapy. – 2001. – Vol. 3, N 5. – Р. 361-364.; Miller G.E., Cohen S. Psychological interventions and the immune system: a meta-analytic review and critique // Health Psychol. – 2001. – Vol. 20, N 1. – P. 47-63.; Montes C.L., Chapoval A.I., Nelson J. Tumor-induced senescent T cells with suppressor function: a potential form of tumor immune evasion // Cancer Res. – 2008. – Vol. 68. – P. 870-879.; Monti D.A., Sufian M., Peterson C. Potential role of mind-body therapies in cancer survivorship // Cancer. – 2008. – Vol. 112, N 11. – Р. 2607-2616.; Norman S.B., Means-Christensen A.J., Craske M.G. Associations between psychological trauma and physical illness in primary care // J. Trauma Stress. – 2006. – Vol. 19, N 4. – Р. 461 - 470.; Ott M.J., Norris R.L., Bauer-Wu S.M. Mindfulness meditation for oncology patients: a discussion and critical review integrative cancer therapies // Integr. Cancer. Ther. – 2006. – Vol. 5, N 2. – Р. 98-108.; Ouyang Q., Baerlocher G., Vulto I. Telomere length in human natural killer cell subsets // Hematopoietic Stem Cells. – 2007. – Vol. 1106. – Р. 240-252.; Reiche E.M., Morimoto H.K., Nunes S.M. Stress and depression-induced immune dysfunction: implications for the development and progression of cancer // Int. Rev. Psychiatry. – 2005. – Vol. 17, N 6. – Р. 515-527.; Rusé-Riol F., Legros M., Bernard D. Variations in committed stem cells (CFU-GM and CFU-TL) in the peripheral blood of cancer patients treated by sequential combination chemotherapy for breast cancer // Cancer Res. – 1984. – Vol. 44. – Р. 2219-2224.; Segerstrom S.C., Miller G.E. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry // Psychol. Bull. – 2004. – Vol. 130, N 4. – Р. 601-630.; Son N.H., Murray Sh., Yanovski J. Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age // J. Immunol. – 2000. – Vol. 165. – Р. 1191 - 1196.; Thaker P.H., Han L.Y., Kamat A.A. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma // Nat. Med. – 2006. – Vol. 12. – P. 939-944.; Thompson H.J. Oxidative DNA damage and cancer risk assessment // J. Nutr. – 2006. – Vol. 136, N 10. – Р. 2693S-2694S.; Vedhara K., Irwin М. Human psychoneuroimmunology. – N.Y.: Oxford Univ. Press, 2005. – 368 р.; Walker L.G. The psychoimmunology of cancer // Cancer Topics. – 2000. – N 11. – Р. 17-19.; Walker L.G., Ratcliffe M.A., Dawson A.A. Relaxation and hypnotherapy: long term effects on the survival of patients with lymphoma // Psycho-Oncology. – 2000. – Vol. 9. – Р. 355-356.; Wood G.J., Bughi S., Morrison J. Hypnosis, differential expression of cytokines by T-cell subsets, and the hypothalamo-pituitary-adrenal axis // Am. J. Clin. Hypn. – 2003. – Vol. 45, N 3. – P. 179 - 196.; Yan B., Wang H., Rabbani Z.N. Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation // Cancer Res. – 2006. – Vol. 66, N 24. – Р. 11565-11570.; Zhou J., Shen X., Huang J. Telomere length of transferred lymphocytes correlates with In vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy // J. Immunol. – 2005. – Vol. 175. – Р. 7046-7052.; https://www.mimmun.ru/mimmun/article/view/259
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