The Therapeutic Effect of Some Drugs and Vegetable Juices on the Lipid Profiles in Male Rabbits induced Atherosclerosis

This study was designed to test the therapeutic efficacy of some hypotensive drugs and vegetable drinks on some biochemical indicators in male rabbits, where atherosclerosis was developed using 1% cholesterol with food. This study was conducted in June until the end of July 2017 in the Pharmacology Department/General Company for Pharmaceutical Industry in Samarra. In the study, 50 local rabbits were randomly distributed by 10 groups, each containing five animals. The first group considered as the control group. The second group is the control group treated with 1% cholesterol with the food, the third group treated with cholesterol (1% and captopril 0.71 mg), group 4 (cholesterol 1% with atenolol 0.71 mg/kg), group 5 (cholesterol 1%, amlodipine 0.07 mg/kg), group 6 treated with cholesterol 1% and aldomet (0.57 mg/kg), group 7 (cholesterol 1% and furosemide at 3.5 mg/kg), group 8 (cholesterol 1% with garlic syrup 2 mL), group 9 treatment cholesterol 1% and lemon juice), and group 10 Treatment with (1% cholesterol and green tea syrup 2 mL). The results of the study showed a significant increase (p less or equal to 0.01)) at the level of each of cholesterol triple and triglycerides, proteins and low density lipoproteins, very low density lipoproteins, also led to obtain a significant decrease in the level of high-density lipoproteins (HDL) in the treatment group with cholesterol 1% compared to control group. At the time of the treatment of anti-pressure drugs: Captopril, Atenolol, Amlodipine, Aldomet, and Furosemide, there were no significant differences in the cholesterol level of all pharmacological groups. Moral differences were not found in LDL-C, and there was a significant decrease (p less or equal to 0.01) of the level of triglycerides, proteins, and very low-density lipoproteins, and there was a significant increase in the level of high-density lipoproteins HDL-C, while treatment with plant juices, there was a significant decrease (p less or equal to 0.01) in the level of total cholesterol and triglycerides ...