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No detection of CD4-independent human immunodeficiency virus 1 envelope glycoproteins in brain tissue of patients with or without neurological complications

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  • Additional Information
    • Contributors:
      Program in Molecular Medicine
    • Publication Date:
      2022
    • Collection:
      University of Massachusetts, Medical School: eScholarship@UMMS
    • Abstract:
      Macrophage (mac)-tropic human immnunodeficiency virus type 1 (HIV-1) and simian immnunodeficiency virus (SIV) in brain are associated with neurological disease. Mac-tropic HIV-1 evolves enhanced CD4 interactions that enable macrophage infection via CD4, which is in low abundance. In contrast, mac-tropic SIV is associated with CD4-independent infection via direct CCR5 binding. Recently, mac-tropic simian-human immunodeficiency virus (SHIV) from macaque brain was also reported to infect cells via CCR5 without CD4. Since SHIV envelope proteins (Envs) are derived from HIV-1, we tested more than 100 HIV-1 clade B Envs for infection of CD4-negative, CCR5(+) Cf2Th/CCR5 cells. However, no infection was detected. Our data suggest that there are differences in the evolution of mac-tropism in SIV and SHIV compared to HIV-1 clade B due to enhanced interactions with CCR5 and CD4, respectively.
    • Relation:
      Link to Article in PubMed; Arch Virol. 2019 Feb;164(2):473-482. doi:10.1007/s00705-018-4094-1. Epub 2018 Nov 10. Link to article on publisher's site; 0304-8608 (Linking); http://hdl.handle.net/20.500.14038/40968; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4781&context=oapubs&unstamped=1; https://escholarship.umassmed.edu/oapubs/3767; oapubs/3767
    • Accession Number:
      10.1007/s00705-018-4094-1
    • Online Access:
      https://doi.org/10.1007/s00705-018-4094-1
      https://doi.org/20.500.14038/40968
      https://hdl.handle.net/20.500.14038/40968
      https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4781&context=oapubs&unstamped=1
      https://escholarship.umassmed.edu/oapubs/3767
    • Rights:
      © The Author(s) 2018. Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. ; http://creativecommons.org/licenses/by/4.0/
    • Accession Number:
      edsbas.34157484