Abstract: Introduction: Dengue, also known as "tropical flu", is an acute viral infection caused by an arbovirus of the flaviviridae family and genus Flavivirus. It is a public health problem in Burkina Faso. Objective: The aim of this study was to understand the determinants of dengue mortality at the CHR in Koudougou in 2023.Methods: This was a cross-sectional study with analytical purpose on probable dengue cases at the CHR of Koudougou from January 1, 2023 to December 31, 2023. The sampling was based on a census of all probable dengue cases received and treated at the CHR in Koudougou during the study period. A validated questionnaire was used for data collection.Results: The mean age of patients was 33.16 years with extremes of 2 and 96 years. The age group 21-31 years was predominant in 33.55% (n=105) of cases; and males in 54.95% (n=172). The majority of cases lived in urban areas in 89.78% (n=281). The study also showed that the probable cases found were most often positive for NS1 antigen in 92.33% (n=289); and presented primary dengue in 84.35% (n=264). The mortality rate was 9.9%. The results of the final multivariate logistic regression model showed that baseline delay (p=0.013), respiratory distress (p=0.002), impaired consciousness (p=0.001), acute renal failure (p=0.041) and comorbidity (p=0.011) were significantly associated with the death of probable dengue cases at the CHR in Koudougou.Conclusion: The lethality of probable dengue cases was high. Baseline delay, respiratory distress, altered consciousness, acute renal failure and co-morbidity were the factors influencing mortality. To better understand these determinants and improve clinical outcomes, more in-depth studies are essential.
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