Characteristics and clinical implications of carbapenemase-producing klebsiella pneumoniae colonization and infection, Italy

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Author(s): Rossi M.; Chatenoud L.; Gona F.; Sala I.; Nattino G.; D'Antonio A.; Castelli D.; Itri T.; Morelli P.; Bigoni S.; Aldieri C.; Martegani R.; Grossi P. A.; Del Curto C.; Piconi S.; Rimoldi S. G.; Brambilla P.; Bonfanti P.; van Hauwermeiren E.; Puoti M.; Gattuso G.; Cerri C.; Raviglione M. C.; Cirillo D. M.; Bandera A.; Gori A.; Battaglia S.; Lorenzin G.; Cavallero A.; Casana M.; Pocaterra D.; Cona A.; D'Arminio Monforte A.; Brigante G.; Carducci A.; Dalla Gasperina D.; Rovelli C.; Moro M.; Scarpellini P.; Rizzardini G.; Pan A.; Zoncada A.; Franzetti M.; Pandolfo A.; Castelli F.; Pollastri E.; Travi G.; Vismara C. S.; Garilli S.; Piazza M.; Regazzetti A.; Arghittu M.; Colombo R. M.; Olivieri P.; Petri F.; Averara F.; Vailati F.
Subject Terms:
CRE; Carbapenem resistance; Enterobacteriaceae; Italy; KPC-Kp; Klebsiella pneumoniae; antimicrobial resistance; bacteria; healthcare-associated infection; mortality rate; Anti-Bacterial Agent; Bacterial Protein; Human; beta-Lactamase; Carbapenem-Resistant Enterobacteriaceae; Klebsiella Infections; Settore MED/17 - Malattie Infettive
Document Type:
article in journal/newspaper
Language:
English

Additional Information
- Contributors:
  M. Rossi; L. Chatenoud; F. Gona; I. Sala; G. Nattino; A. D'Antonio; D. Castelli; T. Itri; P. Morelli; S. Bigoni; C. Aldieri; R. Martegani; P.A. Grossi; C. Del Curto; S. Piconi; S.G. Rimoldi; P. Brambilla; P. Bonfanti; E. van Hauwermeiren; M. Puoti; G. Gattuso; C. Cerri; M.C. Raviglione; D.M. Cirillo; A. Bandera; A. Gori; S. Battaglia; G. Lorenzin; A. Cavallero; M. Casana; D. Pocaterra; A. Cona; A. D'Arminio Monforte; G. Brigante; A. Carducci; D. Dalla Gasperina; C. Rovelli; M. Moro; P. Scarpellini; G. Rizzardini; A. Pan; A. Zoncada; M. Franzetti; A. Pandolfo; F. Castelli; E. Pollastri; G. Travi; C.S. Vismara; S. Garilli; M. Piazza; A. Regazzetti; M. Arghittu; R.M. Colombo; P. Olivieri; F. Petri; F. Averara; F. Vailati
- Publication Information:
  Centers for Disease Control and Prevention (CDC)
- Publication Date:
  2021
- Collection:
  The University of Milan: Archivio Istituzionale della Ricerca (AIR)
- Abstract:
  Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) has been endemic in Italy since 2013. In a multicenter cohort study, we investigated various aspects of KPC-Kp among patients, including 15-day mortality rates and delays in adequate therapy. Most (77%) KPC-Kp strains were sequence types ST512 or ST307. During 2017, KPC-Kp prevalence was 3.26 cases/1,000 hospitalized patients. Cumulative incidence of KPC-Kp acquired >48 hours after hospital admission was 0.68% but varied widely between centers. Among patients with mild infections and noninfected colonized patients, 15-day mortality rates were comparable, but rates were much higher among patients with severe infections. Delays of >4 days in receiving adequate therapy more frequently occurred among patients with mild infections than those with severe infections, and delays were less common for patients with known previous KPC-Kp colonization. Italy urgently needs a concerted surveillance system to control the spread of KPC-Kp.
- Relation:
  info:eu-repo/semantics/altIdentifier/pmid/33900910; info:eu-repo/semantics/altIdentifier/wos/WOS:000650121700019; volume:27; issue:5; firstpage:1416; lastpage:1426; numberofpages:11; journal:EMERGING INFECTIOUS DISEASES; http://hdl.handle.net/2434/899789; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85105297320
- Accession Number:
  10.3201/eid2705.203662
- Online Access:
  https://doi.org/10.3201/eid2705.203662
  http://hdl.handle.net/2434/899789
- Rights:
  info:eu-repo/semantics/openAccess
- Accession Number:
  edsbas.3DB32EC3

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