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Towards a standardized bioinformatics infrastructure for N- and O-glycomics

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  • Additional Information
    • Publication Information:
      Nature Publishing Group
    • Publication Date:
      2019
    • Collection:
      Griffith University: Griffith Research Online
    • Abstract:
      The mass spectrometry (MS)-based analysis of free polysaccharides and glycans released from proteins, lipids and proteoglycans increasingly relies on databases and software. Here, we review progress in the bioinformatics analysis of protein-released N- and O-linked glycans (N- and O-glycomics) and propose an e-infrastructure to overcome current deficits in data and experimental transparency. This workflow enables the standardized submission of MS-based glycomics information into the public repository UniCarb-DR. It implements the MIRAGE (Minimum Requirement for A Glycomics Experiment) reporting guidelines, storage of unprocessed MS data in the GlycoPOST repository and glycan structure registration using the GlyTouCan registry, thereby supporting the development and extension of a glycan structure knowledgebase. ; Full Text
    • Relation:
      Nature Communications; Rojas-Macias, MA; Mariethoz, J; Andersson, P; Jin, C; Venkatakrishnan, V; Aoki, NP; Shinmachi, D; Ashwood, C; Madunic, K; Zhang, T; Miller, RL; Horlacher, O; Struwe, WB; Watanabe, Y; Okuda, S; Levander, F; Kolarich, D; Rudd, PM; Wuhrer, M; Kettner, C; Packer, NH; Aoki-Kinoshita, KF; Lisacek, F; Karlsson, NG, Towards a standardized bioinformatics infrastructure for N- and O-glycomics, Nature Communications, 2019, 10 (1); http://hdl.handle.net/10072/390989
    • Accession Number:
      10.1038/s41467-019-11131-x
    • Online Access:
      http://hdl.handle.net/10072/390989
      https://doi.org/10.1038/s41467-019-11131-x
    • Rights:
      http://creativecommons.org/licenses/by/4.0/ ; © The Author(s). 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. ; open access
    • Accession Number:
      edsbas.4176F2D0