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Current Views on the Pathogenesis and Principles of External Treatment of Atopic Dermatitis in Children ; Современные представления о патогенезе и принципах наружной терапии атопического дерматита у детей

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  • Additional Information
    • Publication Information:
      Издательство «ПедиатрЪ»
    • Publication Date:
      2016
    • Collection:
      Current Pediatrics (Voprosy Sovremennoi Pediatrii - E-Journal) / Вопросы современной педиатрии
    • Abstract:
      The article analyzes the current data on the pathogenesis of atopic dermatitis. It discusses the role of the damaged dermal barrier structure in the development of food allergies and presents the results confirming the theory of transdermal sensibilisation to allergens in addition to hereditary and exogenous factors. Current local treatment of atopic dermatitis using topical glucocorticosteroids (tGCs) aimed at reducing the severity of symptoms is often associated with the risk of complications. The data on the effective use of topical calcineurin inhibitors (TCI) to eliminate the side effects of tGCs are presented. The results of the possible use of pimecrolimus in the form of 1% cream for gradual withdrawal of tGCs in the long-term use are shown. The data of reviews and meta-analyses for the last decade are given showing that there is no evidence that the use of TIC is associated with an increased risk of lymphoma. The authors conclude that pimecrolimus in the form of 1% cream is the best medication for topical therapy in children with mild and moderate form of the disease. It is also considered the best preparation for the proactive treatment of atopic dermatitis in the long period of time in order to prevent recurrences. ; статье анализируются современные данные о патогенезе атопического дерматита. Обсуждается роль нарушения структуры дермального барьера в развитии пищевой аллергии, приводятся результаты, подтверждающие теорию чрескожной сенсибилизации к аллергенам наряду с наследственными и экзогенными факторами. Современная локальная терапия атопического дерматита с использованием топических глюкокортикостероидов (тГКС), направленная на уменьшение выраженности симптомов заболевания, зачастую сопряжена с риском развития осложнений. Приводятся данные об эффективном использовании топических ингибиторов кальциневрина (тИК) в качестве средств, нивелирующих побочные эффекты тГКС. Продемонстрированы результаты возможного применения пимекролимуса в виде 1% крема с целью постепенной отмены тГКС при долгосрочном ...
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    • Relation:
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    • Accession Number:
      10.15690/vsp.v15i6.1655
    • Online Access:
      https://doi.org/10.15690/vsp.v15i6.1655
      https://doi.org/10.1016/s0140-6736(94)92473-2
      https://doi.org/10.1016/S0140-6736(03)12193-9
      https://doi.org/10.1016/j.jaci.2006.03.037
      https://doi.org/10.1016/S0140-6736(15)00149-X
      https://doi.org/10.1016/j.jaci.2006.04.043
      https://doi.org/10.1038/jid.2008.88
      https://doi.org/10.1111/j.1398
      https://doi.org/10.2500/aap2007.28.3041
      https://doi.org/10.1038/ng.2642
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      edsbas.4640A4AD