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A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

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  • Additional Information
    • Publication Information:
      Elsevier
    • Collection:
      CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas)
    • Abstract:
      Despite the frightening mortality rate associated with COVID-19, there is no known approved drug to effectively combat the pandemic. COVID-19 clinical manifestations include fever, fatigue, cough, shortness of breath, and other complications. At present, there is no known effective treatment or vaccine that can mitigate/inhibit SARS-CoV-2. Available clinical intervention for COVID-19 is only palliative and limited to support. Thus, there is an exigent need for effective and non-invasive treatment. This article evaluates the possible mechanism of actions of SARS-CoV-2 and present Nigeria based medicinal plants which have pharmacological and biological activities that can mitigate the hallmarks of the pathogenesis of COVID-19. SARS-CoV-2 mode of actions includes hyper-inflammation characterized by a severe and fatal hyper-cytokinaemia with multi-organ failure; immunosuppression; reduction of angiotensin-converting enzyme 2 (ACE2) to enhance pulmonary vascular permeability causing damage to the alveoli; and further activated by open reading frame (ORF)3a, ORF3b, and ORF7a via c-Jun N- terminal kinase (JNK) pathway which induces lung damage. These mechanisms of action of SARS-CoV-2 can be mitigated by a combination therapy of medicinal herbs based on their pharmacological activities. Since the clinical manifestations of COVID-19 are multifactorial with co-morbidities, we strongly recommend the use of combined therapy such that two or more herbs with specific therapeutic actions are administered to combat the mediators of the disease. ; Fil: Oladele, Johnson O. Kings University; Nigeria ; Fil: Ajayi, Ebenezer Idowu O. Osun State University; Nigeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina ; Fil: Oyeleke, Oyedotun M. Kings University; Nigeria ; Fil: Oladele, Oluwaseun T. Osun State ...
    • File Description:
      application/pdf
    • ISSN:
      2405-8440
    • Relation:
      info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/heliyon/fulltext/S2405-8440(20)31740-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405844020317400%3Fshowall%3Dtrue; http://hdl.handle.net/11336/124423; Oladele, Johnson O.; Ajayi, Ebenezer Idowu O; Oyeleke, Oyedotun M.; Oladele, Oluwaseun T.; Olowookere, Boyede D.; et al.; A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants; Elsevier; Heliyon; 6; 9; 1-9-2020; 1-17; CONICET Digital; CONICET
    • Online Access:
      http://hdl.handle.net/11336/124423
    • Rights:
      info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
    • Accession Number:
      edsbas.5400D346