Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Publication Information:
      Elsevier
    • Publication Date:
      2023
    • Collection:
      Dipòsit Digital de la Universitat de Barcelona
    • Abstract:
      Introduction: The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. Objective: To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. Methods: In 5899 participants aged 55-75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Results: Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (β-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015). Conclusion: Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in ...
    • File Description:
      10 p.; application/pdf
    • Relation:
      Reproducció del document publicat a: https://doi.org/10.1016/j.envres.2023.115697; Environmental Research, 2023, vol. 227, p. 115697; https://doi.org/10.1016/j.envres.2023.115697; https://hdl.handle.net/2445/201403; 733179
    • Online Access:
      https://hdl.handle.net/2445/201403
    • Rights:
      cc-by (c) Khoury, Nadine et al., 2023 ; http://creativecommons.org/licenses/by/3.0/es/ ; info:eu-repo/semantics/openAccess
    • Accession Number:
      edsbas.5E7B386A