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Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019

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  • Additional Information
    • Contributors:
      Karolinska Institutet Stockholm; Institute of Tropical Medicine Antwerp (ITM); Amsterdam University Medical Centers (Amsterdam UMC); Swiss Tropical and Public Health Institute Basel; Biologie Intégrée du Globule Rouge (BIGR (UMR_S_1134 / U1134)); Institut National de la Transfusion Sanguine Paris (INTS)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre / Abymes Guadeloupe -Université des Antilles (UA)-Université Paris Cité (UPCité); Hôpital privé du Confluent Nantes; Institut de recherche en santé, environnement et travail (Irset); Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique); Charité - UniversitätsMedizin = Berlin University Medicine; Alma Mater Studiorum Università di Bologna = University of Bologna (UNIBO); University Hospital of Cologne Cologne
    • Publication Information:
      CCSD
      Elsevier
    • Publication Date:
      2022
    • Collection:
      Inserm: HAL (Institut national de la santé et de la recherche médicale)
    • Abstract:
      International audience ; OBJECTIVES: Cutaneous leishmaniasis (CL) in Asia, Northern, and Sub-Saharan Africa is mainly caused by Leishmania major and Leishmania tropica. We describe and evaluate the treatment outcome of CL among travelers and migrants in Europe.METHODS: We conducted a retrospective study of parasitological confirmed CL cases caused by L. major and L. tropica during 2013-2019 in Europe. Data were collected from medical records and databases within the LeishMan network.RESULTS: Of 206 included cases of CL, 75 were identified as L. major and 131 as L. tropica. Of patients with L. tropica infection, 80% were migrants, whereas 53% of patients with L. major infection had been visiting friends and relatives. Among patients with L. tropica, 48% were younger than 15 years. Pentavalent antimony cured 73% (L. major) and 78% (L. tropica) of patients. The cure rate for intralesional administration was 86% and 67% for systemic, on L. tropica. Liposomal amphotericin B had a cure rate of 44-63%. CONCLUSION: L. major infections were mostly found in individuals visiting friends and relatives, whereas L. tropica were mainly identified in migrants. No patients with L. major relapsed. Pentavalent antimony, liposomal amphotericin B, and cryotherapy had cure rates in accordance with previous studies.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/35728749; PUBMED: 35728749
    • Accession Number:
      10.1016/j.ijid.2022.06.025
    • Online Access:
      https://hal.science/hal-03763669
      https://hal.science/hal-03763669v1/document
      https://hal.science/hal-03763669v1/file/PIIS1201971222003605.pdf
      https://doi.org/10.1016/j.ijid.2022.06.025
    • Rights:
      http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
    • Accession Number:
      edsbas.5EB0B3DD