Contributors: CIC1425 - Bichat AP-HP Hôpital Bichat - Claude Bernard; AP-HP - Hôpital Bichat - Claude Bernard Paris; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7); UFR médecine - Bichat; Université Paris Diderot - Paris 7 (UPD7)-PRES Sorbonne Paris Cité; Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)); Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM); Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)); Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Laboratoire Chrono-environnement (UMR 6249) (LCE); Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC); Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC); Service des maladies infectieuses et tropicales; Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques; Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu Nancy; Service d'Odontologie CHRU Nancy; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy); Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA); Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS); Service des maladies infectieuses et réanimation médicale Rennes = Infectious Disease and Intensive Care Rennes; Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou; Polyclinique de Courlancy; Centre d'Investigation Clinique de Besançon (Inserm CIC 1431); Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang Bourgogne-Franche-Comté (EFS BFC)-Université de Franche-Comté (UFC); Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon); Centre d'investigation clinique Nancy (CIC); Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL); Institut de cardiologie CHU Pitié-Salpêtrière; CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane); Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre / Abymes Guadeloupe -Centre Hospitalier Andrée Rosemon Cayenne, Guyane Française -Centre Hospitalier Universitaire de Martinique Fort-de-France, Martinique (CHU de Martinique); Service des Maladies Infectieuses et Tropicales Point-à-Pitre; CHU Pointe-à-Pitre / Abymes Guadeloupe; Maladies infectieuses et tropicales dans la Caraïbe (MAITC EA 4537); CHU Pointe-à-Pitre / Abymes Guadeloupe -Centre Hospitalier Universitaire de Martinique Fort-de-France, Martinique (CHU de Martinique)-Université des Antilles (UA); Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC); Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL); French ministry of Health; Société Française de Cardiologie and Fédération Française de Cardiologie (grant 2009); Inserm XM/GB/2009-051
Abstract: International audience ; AIMS:To compare oral hygiene habits, oro-dental status, and dental procedures in patients with infective endocarditis (IE) according to whether the IE-causing microorganism originated in the oral cavity.METHODS:We conducted an assessor-blinded case-control study in 6 French tertiary-care hospitals. Oral hygiene habits were recorded using a self-administered questionnaire. Oro-dental status was analysed by trained dental practitioners blinded to the microorganism, using standardized clinical examination and dental panoramic tomography. History of dental procedures was obtained through patient and dentist interviews. Microorganisms were categorised as oral streptococci or non-oral pathogens using an expert-validated list kept confidential during the course of the study. Cases and controls had definite IE caused either by oral streptococci or non-oral pathogens, respectively. Participants were enrolled between May 2008 and January 2013.RESULTS:Cases (n=73) were more likely than controls (n=192) to be aged < 65 years (OR: 2.85; 95% CI 1.41-5.76), to be female (OR: 2.62; 95% CI 1.20-5.74), to have native valve disease (OR: 2.44; 95% CI: 1.16-5.13), to use toothpicks, dental water jet, interdental brush and/or flossing (OR: 3.48; 95% CI: 1.30-9.32), and to have had dental procedures during the prior three months (OR: 3.31; 95% CI: 1.18-9.29), while they were less likely to brush teeth after meals. Gingival inflammation, calculus and infectious dental diseases were not significantly different between groups.CONCLUSIONS:Patients with IE caused by oral streptococci differ from patients with IE caused by non-oral pathogens regarding background characteristics, oral hygiene habits, and recent dental procedures, but not current oro-dental status.
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