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Use of Amniotic Membrane and Its Derived Products for Bone Regeneration: A Systematic Review

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  • Additional Information
    • Contributors:
      Bioingénierie tissulaire (BIOTIS); Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM); Service de chirurgie maxillo-faciale et stomatologie CHU Bordeaux; Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux)-Groupe hospitalier Pellegrin; Biomatériaux et inflammation en site osseux - EA 4691 (BIOS); Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-SFR CAP Santé (Champagne-Ardenne Picardie Santé); Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA); University "G. d'Annunzio" of Chieti-Pescara Chieti; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Research Center of AUVA; Austrian Cluster for Tissue Regeneration; Service de Chirurgie Orthopédique Traumatologique et Plastique Besançon; Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC); Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC); Nanomédecine, imagerie, thérapeutique - UFC (UR 4662) (NIT / NANOMEDECINE); Université de Franche-Comté (UFC)
    • Publication Information:
      CCSD
      Frontiers
    • Publication Date:
      2021
    • Collection:
      Université de Franche-Comté (UFC): HAL
    • Abstract:
      International audience ; Thanks to their biological properties, amniotic membrane (AM), and its derivatives are considered as an attractive reservoir of stem cells and biological scaffolds for bone regenerative medicine. The objective of this systematic review was to assess the benefit of using AM and amniotic membrane-derived products for bone regeneration. An electronic search of the MEDLINE-Pubmed database and the Scopus database was carried out and the selection of articles was performed following PRISMA guidelines. This systematic review included 42 articles taking into consideration the studies in which AM, amniotic-derived epithelial cells (AECs), and amniotic mesenchymal stromal cells (AMSCs) show promising results for bone regeneration in animal models. Moreover, this review also presents some commercialized products derived from AM and discusses their application modalities. Finally, AM therapeutic benefit is highlighted in the reported clinical studies. This study is the first one to systematically review the therapeutic benefits of AM and amniotic membrane-derived products for bone defect healing. The AM is a promising alternative to the commercially available membranes used for guided bone regeneration. Additionally, AECs and AMSCs associated with an appropriate scaffold may also be ideal candidates for tissue engineering strategies applied to bone healing. Here, we summarized these findings and highlighted the relevance of these different products for bone regeneration.
    • Accession Number:
      10.3389/fbioe.2021.661332
    • Online Access:
      https://hal.univ-reims.fr/hal-03429541
      https://hal.univ-reims.fr/hal-03429541v1/document
      https://hal.univ-reims.fr/hal-03429541v1/file/Etchebarne%20et%20al.%20%282021%29%20-%20Use%20of%20Amniotic%20Membrane%20and%20Its%20Derived%20Products%20for%20Bone%20Regeneration-%20A%20Systematic%20Review.pdf
      https://doi.org/10.3389/fbioe.2021.661332
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • Accession Number:
      edsbas.6663C7D1