A Comparative Study of Lipid Profile in Obese and Non-Obese Type 2 Diabetic Patients

BACKGROUND AND OBJECTIVES: The present study is conducted to compare the lipid profile in obese and non-obese patients with type 2 Diabetes Mellitus. All type 2 diabetic patients are at higher risk for cardiovascular and coronary artery disease morbidity and mortality than general population. It is well known fact that liver plays an important role in maintenance of normal glucose levels during fasting as well as post prandial period. In this study is conducted to compare the lipid profile in obese and non-obese patients with type 2 Diabetes Mellitus. Early detection of risk factors will help us to eliminate the effects and complication due to abnormal BMI and deranged lipid profile. METHOD: A hospital based prospective, case control study to compare the lipid profile levels obese and non-obese type 2 diabetic patients. 150 subjects coming to Gen Med OP and IP who meet the inclusion and exclusion criteria will be divided into 2 groups. GROUP I - TYPE 2 DIABETES WITH OBESITY (75). GROUP II - TYPE 2 DIABETES WITH NON OBESITY (75). RESULTS: From the study the cholesterol levels in 48% of obese T2DM patients and 50% of obese non diabetics showed increased values. The triglycerides were increased in 68% of obese T2DM patients and only 48% of the obese non diabetics showed increased values. The LDL-C levels were increased in 64% of obese T2DM, where only 44% of the obese non diabetics had increased values. The VLDL-C levels were increased in 50% of obese T2DM, where only 26% of the obese non diabetic’s had increased values. The HDL-C levels were decreased in 38% of obese T2DM; whereas only 26% of the obese non diabetics had decreased values. The study showed widespread lipid abnormalities in the course of diabetes triggered dyslipidemia as hypercholesterolemia, hypertriglyceridemia, elevated LDL and decreased HDL. This study proposes the predominance of hyperlipidemia over increased prevalence of diabetic dyslipidemia. CONCLUSION: As BMI increases total cholesterol, LDL, TGL, TC/HDL ratio increases and HDL decreases. ...