Abstract: Dietary restriction extends the lifespan of numerous, evolutionarily diverse species. In D. melanogaster, a prominent model for research on the interaction between nutrition and longevity, dietary restriction is typically based on medium dilution, with possible compensatory ingestion commonly being neglected. Possible problems with this approach are revealed by using a method for direct monitoring of D. melanogaster feeding behavior. This demonstrates that dietary restriction elicits robust compensatory changes in food consumption. As a result, the effect of medium dilution is overestimated and, in certain cases, even fully compensated for. Our results strongly indicate that feeding behavior and nutritional composition act concertedly to determine fly lifespan. Feeding behavior thus emerges as a central element in D. melanogaster aging. ; © 2005 Nature Publishing Group. Published 21 October 2005. Supported by a Lawrence L. and Audrey W. Ferguson Fellowship from the Caltech Division of Biology to G.B.C., a grant from the American Federation for Aging Research and a postdoctoral fellowship from the John Douglas French Foundation for Alzheimer's Research to P.K., and grants to S.B. from the US National Institutes of Health (AG16630, AG24366 and DK070154), the National Science Foundation (MCB-0418479) and the Ellison foundation. ; Accepted Version - nihms137890.pdf Supplemental Material - nmeth798-S1.pdf
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