Abstract: [eng] This study investigates the effect of inflammation in MIA-induced osteoarthritis on cardiovascular physiological function in male rats Osteoarthritis (OA) is the most common joint disease in adults worldwide and osteoarthritis of the knee is the most common type. The most common symptom of osteoarthritis is joint pain. Osteoarthritis is a common degenerative disorder of articular cartilage, accompanied by hypertrophic changes in the subchondral bone, which causes inflammation of the surrounding tissues. Studies have shown that systemic and chronic inflammation can increase the risk of cardiovascular disease. Because synovial inflammation is involved in the early stages of OA, one of the side effects of OA is CVD. OA is associated with mild to moderate pain symptoms and the first line of treatment for this disease is the use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as celecoxib. However, the dangerous side effects of NSAIDs in the development of cardiovascular disease in these individuals limit the long-term use of NSAIDs. Using alternative methods such as the use of herbs can prevent side effects. Among these plants is Papaver rhoeas with the scientific name (Papaver rhoeas L.) which has anti-inflammatory properties and is effective in vascular congestion. ; [spa] Este estudio investiga el efecto de la inflamación en la osteoartritis inducida por MIA sobre la función fisiológica cardiovascular en ratas macho. La osteoartritis (OA) es la enfermedad articular más común en adultos en todo el mundo y la osteoartritis de rodilla es el tipo más común. El síntoma más común de la osteoartritis es el dolor articular. La osteoartritis es un trastorno degenerativo común del cartílago articular, acompañado de cambios hipertróficos en el hueso subcondral, que causa inflamación de los tejidos circundantes. Los estudios han demostrado que la inflamación sistémica y crónica puede aumentar el riesgo de enfermedad cardiovascular. Debido a que la inflamación sinovial está involucrada en las primeras etapas de la ...
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