Additional file 1 of RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21

Additional file 1: Figure S1. Supplemental molecular modeling of the RGS6-Nucleolin complex. Figure S2. RSG6 modules expression of Nucleolin and Nucleophosmin in human cardiomyocytes. Figure S3. RGS6 promotes nucleolar stress-driven cell death by down-regulating Nucleolin in human myocytes. Figure S4. RGS6 controls expression of miRNA-21 and target genes in murine VCM. Figure S5. Chemotherapy alters expression of miRNA-21 target genes in human and murine myocardium. Figure S6. RGS6 drives changes in nucleolar function in murine VCM. Figure S7. Inhibition of miRNA-21 or Nucleolin depletion phenocopies the impact of RGS6 on nucleolar stress in human cardiomyocytes. Table S1. Reagent List. TableS2. Cell Line List. Table S3. Antibody List. Table S4. Assay Kit List. Table S5. Primer List. Table S6. The residues undergoing significant change in the solvent accessible surface area (SASA) upon complex formation between RGS6 and Nucleolin. Table S7. Clinical Data for chemotherapy-treated heart autopsy samples: controls (Con) 1-12; chemotherapy patients without detectable fibrosis (C-F) 1-8; and chemotherapy patients with detectable fibrosis (C+F) 1-8.