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Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect

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  • Additional Information
    • Contributors:
      Rodríguez-Pérez,MD; De La Cruz,JP; González-Correa,JA Department of Pharmacology, Faculty of Medicine, Biomedical Research Institute (IBIMA), University of Malaga, Málaga, Spain. López-Villodres,JA; Ríos,MC Area of Human Histology, Faculty of Medicine, University of Malaga, Málaga, Spain. Arrebola,MM Clinical Laboratory, Clinical Management Unit, Hospital Axarquía, AGSEMA, Málaga, Spain. Martín-Aurioles,E Clinical Management Unit La Roca, Distrito Sanitario, AGSEMA, Málaga, Spain. Fernández-Prior,A; Bermúdez-Oria,A Department of Food Phytochemistry, Instituto de la Grasa (Spanish National Research Council, CSIC), Seville, Spain.; This study was supported in part by the Consejería de Salud. Junta de Andalucía (Spain), Proyectos de Investigación en Salud (Regional Ministry of Health. Junta de Andalucía (Spain), Health Research Projects) (PI-0129-2017) and by Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness) (Spain), Centro para el Desarrollo Tecnológico Industrial (Center for the Development of Industrial Technology), FEDER Interconecta Pluri-Regional Program (Spain), (PS17173. NUTRADAF, ITC-20161265).
    • Publication Information:
      MDPI
    • Publication Date:
      2021
    • Collection:
      Sistema Sanitario Público de Andalucía (SSPA): Repositorio
    • Abstract:
      The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67-73%), calculated creatinine clearance was significantly increased (26-38%), and the glomerular volume and glomerulosclerosis index were decreased (20-30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production. ; Yes
    • File Description:
      application/pdf
    • ISSN:
      2076-3921
    • Relation:
      https://www.mdpi.com/2076-3921/10/11/1783/htm; Rodríguez-Pérez MD, López-Villodres JA, Arrebola MM, Martín-Aurioles E, Fernández-Prior Á, Bermúdez-Oria A, et al. Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect. Antioxidants. 2021 Nov 8;10(11):1783; http://hdl.handle.net/10668/4338; PMC8615082
    • Accession Number:
      10.3390/antiox10111783
    • Online Access:
      http://hdl.handle.net/10668/4338
      https://doi.org/10.3390/antiox10111783
    • Rights:
      Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0/ ; open access
    • Accession Number:
      edsbas.7CAD4238