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Epidermal Growth Factor Receptor Mutation In Patients With Non-Small Cell Lung Carcinoma In Fundacion Valle Del Lili, A University Hospital Of Reference In Latin America

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  • Additional Information
    • Publication Information:
      American Lung Association
      Elsevier
      Facultad Ciencias de la Salud
      Medicina
      Departamento de Ciencias Básicas Médicas
      New York
    • Publication Date:
      2016
    • Collection:
      Universidad Icesi, Colombia: Biblioteca Digital
    • Subject Terms:
      New York de Lat: 40 42 00 N degrees minutes Lat: 40.7000 decimal degrees Long: 074 00 00 W degrees minutes Long: -74.0000 decimal degrees
    • Abstract:
      Epidermal Growth Factor Receptor (EGFR) exon 19-deletion and exon 21 L858R mutation is found in 10% of Non-Small Cell Lung Carcinoma (NSCLC) in Caucasians and in 20 to 40% in Asians. The use of Tyrosine Kinase Inhibitors (TKI) in these genetic alterations has demonstrated a greater response and progression free survival in 9-15 months. Objective: To describe the experience in EGFR identification in Fundación Valle del Lili (FVL). Materials and Methods Between June/2013 and Sep/2015, 95 samples were analyzed. A microdissection of tumor areas was performed as well as DNA extraction with QIAamp FFPE Kit(Qiagen®) and amplification of exons 18, 19, 20 and 21 by PCR. It was visualized through microfluidic electrophoresis with Agilent Bioanalyzer® System. Results 98 samples were analyzed. Amplified DNA was obtained in 97% (95) of the cases. The mean age was 65,4±12 years, 63,2% (60) females and 36,8% (35) males. The mutation was observed in 25% (24), exon 19 in 10,5% and exon 21 in 14,7%. 83,1% of the tumors were adenocarcinomas, 70,5% in stage IV and 29% of the cases with a mutation was receiving TKI. Mortality was 14,7% .
    • File Description:
      1 página; Digital; application/pdf; text/html
    • ISSN:
      0041-0101
    • Relation:
      American Journal of Respiratory and Critical Care Medicine, Vol: 193 - 2016; http://nebulosa.icesi.edu.co:2143/full_record.do?product=WOS&search_mode=GeneralSearch&qid=7&SID=3Dr7QVLgmeqIWKgWekv&page=1&doc=1; http://hdl.handle.net/10906/81356; instname: Universidad Icesi; reponame: Biblioteca Digital; repourl: https://repository.icesi.edu.co/
    • Accession Number:
      10.1164/ajrccm-conference.2016.193.1_MeetingAbstracts.A2589
    • Online Access:
      http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2016.193.1_MeetingAbstracts.A2589
      http://nebulosa.icesi.edu.co:2143/full_record.do?product=WOS&search_mode=GeneralSearch&qid=7&SID=3Dr7QVLgmeqIWKgWekv&page=1&doc=1
      http://hdl.handle.net/10906/81356
    • Rights:
      EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor. ; https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/openAccess ; Atribuci�n-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) ; http://purl.org/coar/access_right/c_abf2
    • Accession Number:
      edsbas.7E9896F9