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Screening of natural compounds identifies ferutinin as an antibacterial and anti-biofilm compound

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  • Additional Information
    • Contributors:
      Pharmaceutical Design and Discovery group; Division of Pharmaceutical Biosciences; Drug Research Program; Divisions of Faculty of Pharmacy; Division of Pharmaceutical Chemistry and Technology; Jari Yli-Kauhaluoma / Principal Investigator; Explorations of Anti Infectives; Anti-infectives research; Medicinal Chemistry research group
    • Publication Information:
      Taylor & Francis
    • Publication Date:
      2022
    • Collection:
      Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto
    • Abstract:
      Antibacterial screenings are most commonly targeted at planktonic bacteria but less effort is dedicated to the exploration of agents acting on biofilms. Here, a natural compounds library was screened against Staphylococcus aureus using a 384-well plate platform to identify compounds preventing biofilm formation. Five structurally diverse hits were selected for follow-up studies: honokiol, tschimganidin, ferutinin, oridonin and deoxyshikonin. The compounds were evaluated against different bacterial species for their capacity to prevent and disrupt biofilms. The development of resistance and cytotoxicity were also investigated. Ferutinin displayed the best antibacterial activity, with a minimum inhibitory, bactericidal and biofilm preventive concentration of 25 mu M against S. aureus. It efficiently disrupted pre-formed biofilms (over 5-log reduction of viable cells) and reduced biofilm formation on a catheter in the presence of neutrophils. This work provides new information on the antibacterial activity of five natural compounds and identified ferutinin as a promising candidate against S. aureus biofilms. ; Peer reviewed
    • File Description:
      application/pdf
    • Relation:
      Gilbert-Girard , S , Reigada , I , Savijoki , K , Yli-Kauhaluoma , J & Fallarero , A 2021 , ' Screening of natural compounds identifies ferutinin as an antibacterial and anti-biofilm compound ' , Biofouling , vol. 37 , no. 7 , pp. 791-807 . https://doi.org/10.1080/08927014.2021.1971655; ORCID: /0000-0003-0370-7653/work/101299151; ORCID: /0000-0003-2338-5698/work/101302585; ORCID: /0000-0003-4799-2011/work/152353249; http://hdl.handle.net/10138/347551; 031c29d8-9f3f-4074-82be-57e5df6ceed2; 000691251800001
    • Online Access:
      http://hdl.handle.net/10138/347551
    • Rights:
      cc_by_nc ; info:eu-repo/semantics/openAccess ; openAccess
    • Accession Number:
      edsbas.88904742