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The transcriptomic response of mixed neuron-glial cell cultures to 1,25-dihydroxyvitamin d3 includes genes limiting the progression of neurodegenerative diseases.

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  • Additional Information
    • Contributors:
      Inserm U836, équipe 7, Nanomédecine et cerveau; Grenoble Institut des Neurosciences (GIN); Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM); INSERM U836, équipe 1, Physiopathologie du cytosquelette; Groupe Physiopathologie du Cytosquelette (GPC); Institut National de la Santé et de la Recherche Médicale (INSERM)- GIN Grenoble Institut des Neurosciences (GIN); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG); Direction de Recherche Fondamentale (CEA) (DRF (CEA)); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)- GIN Grenoble Institut des Neurosciences (GIN); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Grenoble Institut des Neurosciences (GIN); Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)
    • Publication Information:
      CCSD
      IOS Press
    • Publication Date:
      2013
    • Collection:
      HAL-CEA (Commissariat à l'énergie atomique et aux énergies alternatives)
    • Abstract:
      International audience ; Seasonal or chronic vitamin D deficiency and/or insufficiency is highly prevalent in the human population. Receptors for 1,25-dihydroxyvitamin D3, the hormonal metabolite of vitamin D, are found throughout the brain. To provide further information on the role of this hormone on brain function, we analyzed the transcriptomic profiles of mixed neuron-glial cell cultures in response to 1,25-dihydroxyvitamin D3. 1,25-dihydroxyvitamin D3 treatment increases the mRNA levels of 27 genes by at least 1.9 fold. Among them, 17 genes were related to neurodegenerative and psychiatric diseases, or brain morphogenesis. Notably, 10 of these genes encode proteins potentially limiting the progression of Alzheimer's disease. These data provide support for a role of 1,25-dihydroxyvitamin D3 in brain disease prevention. The possible consequences of circannual or chronic vitamin D insufficiencies on a tissue with a low regenerative potential such as the brain should be considered.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/23455988; PUBMED: 23455988
    • Accession Number:
      10.3233/JAD-122005
    • Online Access:
      https://inserm.hal.science/inserm-00838410
      https://inserm.hal.science/inserm-00838410v1/document
      https://inserm.hal.science/inserm-00838410v1/file/Nissou_2013_The_transcriptomic_response_AA.pdf
      https://inserm.hal.science/inserm-00838410v1/file/inserm-00838410_edited.pdf
      https://doi.org/10.3233/JAD-122005
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • Accession Number:
      edsbas.8F280EFB