Preparation of Multifunctional Nanofibrous Membranes and Their Application in Promoting Burn Wound Healing

Burns are serious skin trauma that affect not only skin function but also the structure and function of other organs, which in turn aggravate tissue damage or promote scar tissue formation. Pyrimidine polymers have excellent antimicrobial and anti-inflammatory properties and good biocompatibility and have a wide range of applications in the biomedical field. In this work, we synthesized a poly(tetrahydropyrimidine) (PTHP) with antimicrobial and antioxidant properties. A fibrous membrane was prepared by the electrostatic spinning technique using thermoplastic polyurethane (TPU), polycaprolactone (PCL), and PTHP as raw materials. It has a three-dimensional network structure and can be used for burn wound treatment. The nanofiber-encapsulated PTHP has both antimicrobial and antioxidant properties and also shows potential anti-inflammatory effects. These properties enable it to meet the complex microenvironment of burn wounds. The prepared PTHP nanofiber membrane has good mechanical properties, biocompatibility, and antibacterial activity, which can accelerate wound healing, and its therapeutic effect is better than that of commercial dressings and burn creams. Meanwhile, during the treatment process, the fiber membrane will not cause secondary injury due to tissue adhesion or lead to melanin deposition. These unique advantages demonstrate the great potential of PTHP nanofibers in treating burns, making them an important alternative for burn treatment.