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From Plant to Probe: Semi-Synthesis of Labelled Undecaprenol Analogues Allows Rapid Access to Probes for Antibiotic Targets
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- Author(s): Cochrane, Rachel; Alexander, Francesca; Boland, Coilin; Fetics, Susan; Caffrey, Martin; Cochrane, Stephen
- Source:
Cochrane, R, Alexander, F, Boland, C, Fetics, S, Caffrey, M & Cochrane, S 2020, 'From Plant to Probe: Semi-Synthesis of Labelled Undecaprenol Analogues Allows Rapid Access to Probes for Antibiotic Targets', Chemical Communications. https://doi.org/10.1039/D0CC03388J
- Document Type:
article in journal/newspaper
- Language:
English
- Additional Information
- Publication Date:
2020
- Collection:
Queen's University Belfast: Research Portal
- Abstract:
Undecaprenol-containing glycolipids (UCGs) are essential precursors of bacterial glycopolymers and glycoproteins. We report a novel semi-synthetic strategy to prepare labelled UCGs directly from undecaprenol. This one-size-fits-all approach offers a concise and efficient method for obtaining labelled-UCGs, which will allow new mechanistic studies and inhibitor screens to be performed on novel antibiotic targets.
- File Description:
application/pdf
- Accession Number:
10.1039/D0CC03388J
- Online Access:
https://pure.qub.ac.uk/en/publications/8f79635a-2b1c-4288-b2d5-9b213a42b16b
https://doi.org/10.1039/D0CC03388J
https://pureadmin.qub.ac.uk/ws/files/213591225/Und_Labelling_Revised_20200629.pdf
- Rights:
info:eu-repo/semantics/openAccess
- Accession Number:
edsbas.96304B8B
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