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Enzymatic generation of highly anticoagulant bovine intestinal heparin

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  • Additional Information
    • Contributors:
      Veteriner Fakültesi; Fizyoloji Ana Bilim Dalı; orcid:0000-0002-5600-8162; Yalçın, Murat; AAG-6956-2021; 57192959734
    • Publication Information:
      Amer Chemical
    • Publication Date:
      2017
    • Collection:
      Açık Erişim@BUU (Bursa Uludağ Üniversitesi)
    • Abstract:
      Unlike USP porcine heparin, bovine intestinal heparin (BIH) has a low anticoagulant activity. Treatment with 6-OST-1,-3, and/or 3-OST-1 afforded two remodeled heparins that met USP heparin activity and Mw specifications. We explored the pharmacodynamics and pharmacokinetics in a rabbit model. We conclude that a modest increase in the content of 3-O-sulfo groups in BIH increases the number of antithrombin III binding sites, making remodeled BIH behave similarly to pharmaceutical heparin. ; United States Department of Health & Human Services National Institutes of Health (NIH) - USA - HL096972 - HL62244 - HL094463 - GM38060
    • Relation:
      Makale - Uluslararası Hakemli Dergi; Journal of Medicinal Chemistry; Yurt dışı; https://doi.org/10.1021/acs.jmedchem.7b01269; http://hdl.handle.net/11452/29361; 000414114300030; 8673; 8679; 60; 20
    • Accession Number:
      10.1021/acs.jmedchem.7b01269
    • Accession Number:
      10.1021/acs.jmedchem.7b01269?cookieSet=1
    • Online Access:
      http://hdl.handle.net/11452/29361
      https://doi.org/10.1021/acs.jmedchem.7b01269
      https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01269?cookieSet=1
    • Rights:
      info:eu-repo/semantics/openAccess
    • Accession Number:
      edsbas.98E4E4D7