Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Model reduction and process analysis of biological models

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Contributors:
      Biological control of artificial ecosystems (BIOCORE); Laboratoire d'océanographie de Villefranche (LOV); Observatoire océanologique de Villefranche-sur-mer (OOVM); Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire océanologique de Villefranche-sur-mer (OOVM); Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM); Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de la Recherche Agronomique (INRA); Modeling, simulation, measurement, and control of bacterial regulatory networks (IBIS); Laboratoire Adaptation et pathogénie des micro-organismes Grenoble (LAPM); Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes; Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Jean Roget; bourse Conseil Régional PACA; ANR-11-BINF-0005,RESET,Eteindre et rallumer la machinerie d'expression génique chez les bactéries: de modèles mathématiques aux applications biotechnologiques(2011)
    • Publication Information:
      HAL CCSD
    • Publication Date:
      2015
    • Collection:
      Université Grenoble Alpes: HAL
    • Subject Terms:
      Torremolinos; Spain
    • Abstract:
      International audience ; Understanding the dynamical behavior of biological networks is complicated due to their large number of components and interactions. We present a method to analyse key processes for the system behavior, based on the a priori knowledge of the system trajectory and the simplification of mathematical models of these networks. The method consists of the model decomposition into biologically meaningful processes, whose activity or inactivity is evaluated during the time evolution of the system. The structure of the model is reduced to the core mechanisms involving active processes only. We assess the quality of the reduction by means of global relative errors and apply our method to two models of the circadian rhythm in Drosophila and the influence of RKIP on the ERK signaling pathway.
    • Relation:
      hal-01239356; https://inria.hal.science/hal-01239356; https://inria.hal.science/hal-01239356/document; https://inria.hal.science/hal-01239356/file/MED2015-paper.pdf
    • Accession Number:
      10.1109/MED.2015.7158908
    • Online Access:
      https://doi.org/10.1109/MED.2015.7158908
      https://inria.hal.science/hal-01239356
      https://inria.hal.science/hal-01239356/document
      https://inria.hal.science/hal-01239356/file/MED2015-paper.pdf
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • Accession Number:
      edsbas.A0B1BAA1