Psychological morbidity in leber’s hereditary optic neuropathy depends on phenotypic, social, economic, and genetic factors

International audience ; We have read with interest the article by Garcia et al about the effect of visual impairment on psychological well-being with regard to mood, interpersonal interactions, and career-related goals. Among the 103 Leber’s hereditary optic neuropathy (LHON) patients, half became depressed with negative impacts on interpersonal relations and career goals. At diagnosis, older age corresponded to higher depression prevalence than young age. We have the following comments and concerns.