Abstract: International audience ; In biology, one of the most challenging problems is how the emergence of self-organization and operational closure are maintained through time. In this topic, phenomena like regulation, replication and reparation have to be defined in order to get a concept of self-organization. Up to now, reparation in metabolic networks has a non trivial description and many efforts have been made to investigate related concepts as closure existence or system dynamics. We propose a model where the coexistence of intermittent coupled dynamical systems allows the emergence of global reparation as a property of the whole network and, also, it is needed to maintain the normal function of the individuality in time.
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