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Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro trypanocidal activity

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  • Additional Information
    • Publication Information:
      Elsevier
    • Publication Date:
      2016
    • Collection:
      dadun - Depósito Académico Digital Universidad de Navarra
    • Abstract:
      We report the synthesis and in vitro activity against T. cruzi epimastigotes of 15 novel quinoxaline derivatives. Ten of the derivatives presented IC50 values lower than the reference drugs Nfx and Bzn; four of them standed out with IC50 values lower than 1.5 M. Moreover, unspecific cytotoxicity and genotoxicity studies are also reported. Compound 14 showed a SI higher than 24, whereas compound 10 was the only one that was negative in the genotoxicity screening.
    • File Description:
      application/pdf
    • Relation:
      https://hdl.handle.net/10171/40413
    • Online Access:
      https://hdl.handle.net/10171/40413
    • Rights:
      info:eu-repo/semantics/openAccess
    • Accession Number:
      edsbas.A899B3A8