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Atorvastatin treatment softens human red blood cells: An optical tweezers study

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  • Additional Information
    • Publication Date:
      2018
    • Collection:
      eprints Iran University of Medical Sciences
    • Abstract:
      Optical tweezers are proven indispensable single-cell micro-manipulation and mechanical phenotyping tools. In this study, we have used optical tweezers for measuring the viscoelastic properties of human red blood cells (RBCs). Comparison of the viscoelastic features of the healthy fresh and atorvastatin treated cells revealed that the drug softens the cells. Using a simple modeling approach, we proposed a molecular model that explains the drug-induced softening of the RBC membrane. Our results suggest that direct interactions between the drug and cytoskeletal components underlie the drug-induced softening of the cells. © 2018 Optical Society of America.
    • File Description:
      text
    • Relation:
      http://eprints.iums.ac.ir/585/1/Atorvastatin%20treatment%20softens%20human%20red%20blood%20cells%20An%20optical%20tweezers%20study.pdf; Sheikh-Hasani, V. and Babaei, M. and Azadbakht, A. and Pazoki-Toroudi, H. and Mashaghi, A. and Moosavi-Movahedi, A.A. and Reihani, S.N.S. (2018) Atorvastatin treatment softens human red blood cells: An optical tweezers study. Biomedical Optics Express, 9 (3).
    • Online Access:
      http://eprints.iums.ac.ir/585/
      http://eprints.iums.ac.ir/585/1/Atorvastatin%20treatment%20softens%20human%20red%20blood%20cells%20An%20optical%20tweezers%20study.pdf
      https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042704881&doi=10.1364%2fBOE.9.001256&partnerID=40&md5=ecf127c414ac6a29d072af7e6bc87af8
    • Accession Number:
      edsbas.A91756A5