Chitosan cosmetic cream: stability and non-clinical studies ; Crema cosmética de quitosano: estudios de estabilidad y no-clínicos ; Creme cosmético de quitosana: estabilidade e estudos não clínicos

Introduction: Chitosan has been used in various products for skin care, hair care, cleaning and other products. These not only provide health benefits, but also excellent cosmetic qualities and efficacy. Objective: To evaluate the stability of a 1.0 % chitosan cosmetic cream, as well as its non-clinical effects. Methods: Three pilot batches of the cosmetic formulation were prepared by the melting method. Physical, chemical and microbiological evaluation was performed for 365 days, under shelf life conditions. The studied parameters were organoleptic characteristics, pH, extensibility, degree of deacetylation and microbiological count. Non-clinical evaluations of the cream included dermal and ophthalmic irritability. The dermoregenerative effect was evaluated in a photoaging model in the skin of mice photosensitized with ultraviolet radiation. Results: The cream was stable for 12 months, packaged in high-density polyethylene bottles at room temperature, and by predictive analysis until to 24 months. The formulated semisolid is safe, being considered a system of low toxicity to the organism, with moderate dermoregenerative activity. Conclusions: The pilot batches maintained their stability for 12 months at 30 ± 2 oC and 70 % relative humidity. The 1.0 % chitosan cream is non-irritating dermally and ophthalmically and has a moderate dermoregenerative effect. ; Introducción: El quitosano se ha empleado en diversos productos para el cuidado de la piel, el cabello, de limpieza, entre otros. Los mismos no solo brindan beneficios para la salud, sino también excelentes cualidades cosméticas y eficacia. Objetivo: Evaluar la estabilidad de una crema cosmética de quitosano al 1,0 %, así como sus efectos no clínicos. Métodos: Se elaboraron tres lotes pilotos de la formulación cosmética por el método de fusión. Se realizó la evaluación física, química y microbiológica por 365 días, en condiciones de vida de estante. Los parámetros estudiados fueron las características organolépticas, pH, extensibilidad, grado de ...