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Toxicity of the acetyl-para-aminophenol group of medicines to intact intervertebral disc tissue cells

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  • Additional Information
    • Publication Information:
      Spandidos Publications Ltd.
    • Publication Date:
      2021
    • Collection:
      İstanbul Medipol University Institutional Repository (DSpace@Medipol)
    • Abstract:
      The present study aimed to investigate the effects of paracetamol, an analgesic and antipyretic that is used in emergency departments and neurosurgery departments for postoperative pain management on intervertebral disc tissue. Paracetamol-treated human primary cell cultures and untreated cell cultures were compared using molecular analyses. Cell proliferation and gene expression were statistically analyzed. Cell proliferation was suppressed on days 10 (P=0.05) and 20 (P<0.05) in the paracetamol-treated groups. Gene expression of chondroadherin, matrix metalloproteinase (MMP)-7, MMP-13 and MMP-19 was higher in the paracetamol-treated samples while gene expression of Cartilage Oligomeric Matrix Protein and interleukin-1 beta was lower (P<0.05). Paracetamol, which appears innocuous compared with many analgesics, may increase the expression of MMPs, which serve a significant role in catabolic reactions and suppress the proliferation of intact intervertebral disc tissue cells. ; Namik Kemal University
    • File Description:
      application/pdf
    • ISSN:
      1792-0981
      1792-1015
    • Relation:
      Experimental and Therapeutic Medicine; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Karaarslan, N., Yılmaz, İ. ve Yaşar Şirin, D. (2021). Toxicity of the acetyl-para-aminophenol group of medicines to intact intervertebral disc tissue cells. Experimental and Therapeutic Medicine, 21(2). https://doi.org/10.3892/etm.2020.9578; https://doi.org/10.3892/etm.2020.9578; https://hdl.handle.net/20.500.12511/6506; 21; Q3
    • Accession Number:
      10.3892/etm.2020.9578
    • Online Access:
      https://hdl.handle.net/20.500.12511/6506
      https://doi.org/10.3892/etm.2020.9578
    • Rights:
      info:eu-repo/semantics/openAccess ; Attribution-NonCommercial-NoDerivatives 4.0 International ; https://creativecommons.org/licenses/by-nc-nd/4.0/
    • Accession Number:
      edsbas.AB63FB47