Novel expression of luteinizing hormone-chorionic gonadotropin receptor in gastrointestinal tract of the rat and its implications in the aetiology of emesis/hyperemesis gravidarum.

by Poon Chuen Wai. ; Thesis (Ph.D.)--Chinese University of Hong Kong, 1996. ; Includes bibliographical references (leaves 161-176). ; Abstract --- p.i ; Acknowledgements --- p.vi ; Abbreviations --- p.viii ; Introduction --- p.1 ; Review of the literature --- p.2 ; Incidence and historical background --- p.3 ; Theories on etiology of emesis/hyperemesis gavidarum --- p.5 ; Mechanism of vomiting --- p.7 ; Temporal association between hCG and emesis/hyperemesis gravidarum --- p.9 ; Thyroid function and emesis/hyperemesis gravidarum --- p.13 ; Steroid hormone and emesis/hyperemesis gravidarum --- p.15 ; Hyperemesis caused by corpus luteum in right ovary --- p.15 ; "Formulation of a new hypothesis for emesis/hyperemesis gravidarum : “hCG stimulated electrolyte and fluid secretion in the UGIT, leading to pregnancy associated vomiting 226}0ح" --- p.16 ; Is hCG a humoural secretory agent ？ --- p.18 ; Can hCG stimulate the secretion of fluid and electrolytes from the GIT ？ --- p.18 ; Are LH-CGR present in the GIT ？ --- p.20 ; Can electrolyte and fluid secretion in the UGIT lead to vomiting during pregnancy ？ --- p.24 ; HCG and regulation of electrolyte and fluid movement --- p.24 ; Gut- gonad axis --- p.25 ; Objectives --- p.27 ; Section 1 hCG and in vitro secretion of anions from cells with functional LH-CGR - A cell model --- p.28 ; Introduction --- p.28 ; Materials and Methods ; Materials --- p.30 ; Methods ; Chapter 1. --- Test for the presence of LH-CGR in human gastrointestinal cell lines --- p.31 ; Chapter 2. --- Establishment of cells expressing functional receptor for hCG --- p.35 ; Chapter 3. --- Effect of hCG on [125I] iodide efflux from COS-1 cells transiently expressing MC1+2 LH-CG/TSH chimera receptor --- p.38 ; Chapter 4. --- Anion secretion from MLTC-1 cells with wild type LH-CGR --- p.38 ; Chapter 5. --- Statistics --- p.41 ; Results --- p.42 ; Discussion --- p.55 ; Section 2 Presence of LH-CGR in the upper gastrointestinal tract of rat --- p.61 ; Introduction --- p.61 ; Materials and Methods ; Materials ...