Abstract: Introduction. Colorectal cancer (CRC) remains one of the most common causes of cancer incidence and mortality, particularly among older adults. Population aging and increased life expectancy contribute to a growing proportion of elderly patients diagnosed with CRC. Considering comorbidities, functional limitations, and a high risk of complications, the choice of optimal surgical management in this population is challenging. Therefore, comparative analyses of different surgical strategies in this patient group present clinical significance. The aim of this study was to perform a comparative analysis of surgical outcomes in elderly patients with colon cancer depending on a surgical approach. Materials and methods. The study included 140 patients who underwent either laparotomic or laparoscopic surgery. Demographic and clinical and pathologic features, intra- and postoperative parameters, complication rates according to the Clavien—Dindo classification, as well as survival outcomes, were assessed. Results. Laparoscopic interventions were associated with shorter hospital stays, while overall survival rates were comparable between the two groups. The frequency of postoperative complications according to the Clavien—Dindo classification was similar; however, grade II complications occurred more frequently in the laparotomy group. No statistically significant differences were observed in postoperative mortality or disease stage between the groups. Discussion. Both current literature and the obtained results confirm the safety and effectiveness of the laparoscopic approach in elderly patients with CRC. Minimally invasive interventions are associated with reduced intraoperative trauma and more favorable postoperative recovery. Nevertheless, careful preoperative selection remains essential, particularly in patients with severe comorbidities. Conclusion. The findings indicate that minimally invasive procedures are safe and highly effective in the surgical management of colorectal cancer in elderly patients. ; Введение. ...
Relation: https://www.surgonco.ru/jour/article/view/1114/662; Старостин Р.А., Гатауллин Б.И., Валитов Б.Р., Гатауллин И.Г. Колоректальный рак: эпидемиология и факторы риска. Поволжский онкологический вестник. 2021;12(4):52–59.; International Agency for Research on Cancer. World fact sheet — GLOBOCAN 2022. Lyon: Global Cancer Observatory, 2023.; Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209–49. DOI:10.3322/caac.21660; Siegel R.L., Miller K.D., Wagle N.S., Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17–48. DOI:10.3322/caac.21763; Ferlay J., Colombet M., Soerjomataram I., Parkin D.M., Piñeros M., Znaor A., et al. Cancer statistics for the year 2020: An overview. Int J Cancer. 2021 Apr 5. DOI:10.1002/ijc.33588; Нековаль В.М., Ефетов С.К., Царьков П.В. Гериатрический подход в лечении пациентов старческого возраста с колоректальным раком. Медицинский совет. 2021;(21-2):72–9. DOI:10.21518/2079701X-2021-21-2-72-79; Щербакова Е.М. Старение населения мира по оценкам ООН 2022 года. Демоскоп Weekly. 2023;975–976:1–30.; World Population Prospects 2022. [cited 2025 Feb 9]. Available from: https://www.un.org/development/desa/pd/content/World-PopulationProspects-2022; Regional Implementation Strategy for the Madrid International Plan of Action on Ageing 2002: Report. Geneva: UN, 2002. [cited 2025 June 10]. Available from: https://unece.org; Черниковский И.Л., Гельфонд В.М., Загрядских А.С., Савчук С.А. Мини-инвазивная хирургия колоректального рака у больных старческого возраста. Сибирский онкологический журнал. 2016;15(3):28–36. DOI:10.21294/1814-4861-2016-15-3-28-36; Фролова Ю.В., Никода В.В., Тюрина Е.А., Дымова О.В., Корчашкина Н.В., Михайлова А.А. и др. Основные факторы риска кардиоваскулярных осложнений на всех этапах хирургического лечения пациентов пожилого и старческого возраста с колоректальным раком и сопутствующей сердечно-сосудистой патологией. Кардиология и сердечно-сосудистая хирургия. 2023;16(2):199–204. DOI:10.17116/kardio202316021199; Глушков Н.И., Горшенин Т.Л., Беликова М.Я., Дулаева С.К., Боровик И.К. Результаты хирургического лечения больных пожилого и старческого возраста с осложненными формами местно-распространенного рака ободочной кишки. Вестник Северо-Западного государственного медицинского университета им. И. И. Мечникова. 2019;11(2):35–42. DOI:10.17816/mechnikov201911235-42; Kojimahara N., Sato Y., Sato Y., Kojimahara F., Takahashi K., Nakatani E. Longitudinal analysis of long-term outcomes of colorectal cancer after laparotomy and laparoscopic surgery: The Shizuoka study. PLoS One. 2023;18(11):e0294589. DOI:10.1371/journal.pone.0294589; Shinji S., Yamada T., Matsuda A., Sonoda H., Ohta R., Iwai T., et al. Recent advances in the treatment of colorectal cancer: a review. J Nippon Med Sch. 2022;89(3):246–54. DOI:10.1272/jnms.JNMS.2022_89-310; Fujii S., Tsukamoto M., Fukushima Y., Shimada R., Okamoto K., Tsuchiya T., et al. Systematic review of laparoscopic vs open surgery for colorectal cancer in elderly patients. World J Gastrointest Oncol. 2016;8(7):573–82. DOI:10.4251/wjgo.v8.i7.573; Майстренко Н.А., Чирский В.С., Сазонов А.А., Ерохина А.А. Комплексный подход в обосновании хирургической тактики при местно-распространенных формах колоректального рака у пациентов старших возрастных групп. Вестник хирургии им. И.И. Грекова. 2019;178(2):38–45. DOI:10.24884/0042-4625-2019-178-2-38-45; Wang C., Gan L., Jiang K., Gao Z., Ye Y. Safety and efficacy of laparoscopic surgery versus open surgery in elderly patients with colon cancer: a propensity score matching cohort study. Dig Surg. 2022;39(5–6):255–62. DOI:10.1159/000529223; Normann M., Ekerstad N., Angenete E., Prytz M. Mortality and morbidity after colorectal cancer resection surgery in elderly patients: a retrospective population-based study in Sweden. World J Surg Oncol. 2024;22(1):23. DOI:10.1186/s12957-024-03316-6; Turri G., Caliskan G., Conti C., Martinelli L., De Giulio E., Ruzzenente A., et al. Impact of age and comorbidities on short- and longterm outcomes of patients undergoing surgery for colorectal cancer. Front Oncol. 2022;12:959650. DOI:10.3389/fonc.2022.959650; Kędzia-Berut R., Berut M., Włodarczyk M., Włodarczyk J., Dziki Ł., Dziki A., et al. Colorectal cancer: Is it still a disease of the elderly? Pol Przegl Chir. 2023;14;96(0):41–5. DOI:10.5604/01.3001.0054.0956; Rossi B.W.P., Labib P., Ewers E., Leong S., Coleman M., Smolarek S. Long-term results after elective laparoscopic surgery for colorectal cancer in octogenarians. Surg Endosc. 2020;34(1):170–6. DOI:10.1007/s00464-019-06747-5; Fontani A., Martellucci J., Civitelli S., Tanzini G. Outcome of surgical treatment of colorectal cancer in the elderly. Updates Surg. 2011;63(4):233–7. DOI:10.1007/s13304-011-0085-4; Chautard J., Alves A., Zalinski S., Bretagnol F., Valleur P., Panis Y. Laparoscopic colorectal surgery in elderly patients: a matched case-control study in 178 patients. J Am Coll Surg. 2008;206(2):255–60. DOI:10.1016/j.jamcollsurg.2007.06.316; Person B., Cera S.M., Sands D.R., Weiss E.G., Vernava A.M., Nogueras J.J., et al. Do elderly patients benefit from laparoscopic colorectal surgery? Surg Endosc. 2008;22(2):401–5. DOI:10.1007/s00464-007-9412-8; Luo W., Wu M., Chen Y. Laparoscopic versus open surgery for elderly patients with colorectal cancer: a systematic review and meta-analysis of matched studies. ANZ J Surg. 2022;92(9):2003–17. DOI:10.1111/ans.17972; Zhang L., Li Q., Hu C., Zhang Z., She J., Shi F. Real-world analysis of survival benefit of surgery and adjuvant therapy in elderly patients with colorectal cancer. Sci Rep. 2023;13(1):14866. DOI:10.1038/s41598-023-41713-1; Hung H.Y., Huang S.H., Tsai T.Y., You J.F., Hsieh P.S., Lai C.C., et al. Comparative analysis of short- and long-term outcomes in laparoscopic versus open surgery for colorectal cancer patients undergoing hemodialysis. Langenbecks Arch Surg. 2024;409(1):250. DOI:10.1007/s00423-024-03440-7; Moug S.J., McCarthy K., Coode-Bate J., Stechman M.J., Hewitt J. Laparoscopic versus open surgery for colorectal cancer in the older person: A systematic review. Ann Med Surg (Lond). 2015;4(3):311–8. DOI:10.1016/j.amsu.2015.08.002; Song J.H., Shin Y., Lee K.H., Kim J.Y., Kim J.S. Correlation between inflammatory markers and enhanced recovery after surgery (ERAS) failure in laparoscopic colectomy. Surg Today. 2024 Nov 20. DOI:10.1007/s00595-024-02958-z; Takano Y., Kai W., Kobayashi Y., Kanno H., Hanyu N. Short-term outcomes of colorectal cancer surgery in patients with dialysis: a systematic review and meta-analysis. Langenbecks Arch Surg. 2023;408(1):283. DOI:10.1007/s00423-023-03016-x; https://www.surgonco.ru/jour/article/view/1114
No Comments.